{"id":"W2102125353","doi":"10.1111/jnc.13117","title":"Exogenous arachidonic acid mediates permeability of human brain microvessel endothelial cells through prostaglandin E<sub>2</sub>activation of<scp>EP</scp><sub>3</sub>and<scp>EP</scp><sub>4</sub>receptors","year":2015,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research; Manitoba Health Research Council; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Microvessel; Arachidonic acid; Receptor; Permeability (electromagnetism); Chemistry; Cell biology; Prostaglandin; Vascular permeability; Neuroscience; Biophysics; Biochemistry; Endocrinology; Biology; Angiogenesis; Cancer research; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001749057,0.0008751561,0.001750311,0.0003180369,0.0002327652,0.00007597096,0.0005252162,0.0006955232,0.000004884525],"category_scores_gemma":[0.004389245,0.0007937108,0.0006653166,0.0004953486,0.0006271037,0.0005429375,0.0001940901,0.001672066,0.00001635725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003827565,"about_ca_system_score_gemma":0.0009742706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009579744,"about_ca_topic_score_gemma":0.000004558412,"domain_scores_codex":[0.9941241,0.000414226,0.002117689,0.0007960073,0.001569076,0.0009789077],"domain_scores_gemma":[0.993146,0.001461474,0.002676225,0.000766317,0.001050496,0.0008994598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003282601,0.0008424061,0.007271967,0.00193317,0.0002665319,0.00020834,0.003454613,0.00002565088,0.9809934,0.00000626376,0.003859356,0.0008099986],"study_design_scores_gemma":[0.005379634,0.001651145,0.008857408,0.00069021,0.0003862723,0.000812742,0.000940755,0.00003621931,0.9802496,0.0002357033,0.000523695,0.0002366238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966252,0.000848204,0.0000692222,0.000155411,0.001075962,0.0008122862,0.000113654,0.00007345273,0.0002266095],"genre_scores_gemma":[0.9968047,0.000636564,0.00009994389,0.0002688588,0.001878893,0.00002677634,0.0000867698,0.0001624348,0.0000350705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005051374,"threshold_uncertainty_score":0.9994514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397643212488191,"score_gpt":0.240178517047898,"score_spread":0.2262020849230161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}