{"id":"W2102182787","doi":"10.1016/s1474-4422(11)70108-9","title":"Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)","year":2011,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":638,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Actelion Pharmaceuticals","keywords":"Endothelin receptor antagonist; Medicine; Glasgow Outcome Scale; Subarachnoid hemorrhage; Placebo; Endovascular coiling; Clinical endpoint; Vasospasm; Anesthesia; Randomized controlled trial; Internal medicine; Aneurysm; Antagonist; Surgery; Endovascular treatment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001016528,0.001750761,0.004192305,0.0004484101,0.0004578849,0.001079492,0.0008192359,0.001980244,0.005657507],"category_scores_gemma":[0.001620145,0.0007639821,0.001965305,0.0005303457,0.001127605,0.001142615,0.0003395129,0.003331682,0.0009183887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005524583,"about_ca_system_score_gemma":0.001040005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001618315,"about_ca_topic_score_gemma":0.003377249,"domain_scores_codex":[0.9995726,0.000178571,0.0000339044,0.00007980115,0.00003762038,0.00009745957],"domain_scores_gemma":[0.999422,0.0001651953,0.0001055101,0.00004839723,0.00004160936,0.0002173262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9867719,0.001587571,0.0002932977,0.0007106423,0.0007712725,0.00003853478,0.00003596059,0.0001130886,0.002181845,0.00005848358,0.0005399681,0.006897454],"study_design_scores_gemma":[0.9839891,0.01412938,0.001061271,0.00001619052,0.0002995793,0.00001762995,0.00001257125,0.0001010962,0.0001348197,0.00004561721,0.0001824763,0.00001033172],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832118,0.008572094,0.0006687219,0.00104674,0.001196114,0.001755393,0.001154701,0.0001845615,0.002209888],"genre_scores_gemma":[0.9799004,0.007213235,0.001480989,0.002102553,0.001163364,0.002831937,0.001486521,0.00003693095,0.003783993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005657507,"threshold_uncertainty_score":0.0189262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0542099779558352,"score_gpt":0.2981004877135117,"score_spread":0.2438905097576765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}