{"id":"W2102227937","doi":"10.1002/cmdc.200800050","title":"Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors","year":2008,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Synthesis and Reactivity of Heterocycles","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Indigenous and Northern Affairs Canada","keywords":"Cysteine protease; Cysteine; Chemistry; Stereochemistry; Enzyme; Protease; Enzyme inhibitor; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227455,0.0003545806,0.0003360321,0.0001653676,0.0001100506,0.0002466189,0.0003054651,0.0002864428,0.001151248],"category_scores_gemma":[0.0001671163,0.00010447,0.0001468071,0.0001860788,0.0001753541,0.0002680544,0.0001497536,0.000283937,0.0002131298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603137,"about_ca_system_score_gemma":0.0002075199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004809404,"about_ca_topic_score_gemma":0.001203667,"domain_scores_codex":[0.9998485,0.00004391119,0.00001105819,0.00002842857,0.00003751269,0.00003051785],"domain_scores_gemma":[0.9999305,0.00002084271,0.00001714673,0.000007476418,0.00001045989,0.00001351382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003200453,0.00008237837,0.0002231725,0.0001639012,0.00001538849,0.0001130801,0.00002994739,0.0004422901,0.9922668,0.0004106997,0.00005693219,0.00587532],"study_design_scores_gemma":[0.00008052828,0.002043056,0.001356596,0.000008776917,0.00002006728,0.0002753666,0.00001920836,0.0007191164,0.9919243,0.00007811293,0.00346547,0.000009334412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882746,0.00692146,0.001616785,0.00006425576,0.00003175326,0.00006254589,0.0001897144,0.00001903043,0.002819761],"genre_scores_gemma":[0.9906574,0.004045489,0.002235682,0.00004533639,0.00001868735,0.00003504454,0.0002272244,0.00001149662,0.002723623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151248,"threshold_uncertainty_score":0.003851235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342293086868059,"score_gpt":0.2100451813010931,"score_spread":0.1966222504324125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}