{"id":"W2102227937","doi":"10.1002/cmdc.200800050","title":"Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors","year":2008,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Synthesis and Reactivity of Heterocycles","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Indigenous and Northern Affairs Canada","keywords":"Cysteine protease; Cysteine; Chemistry; Stereochemistry; Enzyme; Protease; Enzyme inhibitor; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008949018,0.0002671111,0.0003031533,0.00004111634,0.0002195607,0.00002865621,0.0001790899,0.0002198858,0.0007825313],"category_scores_gemma":[0.0001252202,0.0002397445,0.0001314696,0.00006241955,0.0003171856,0.0001383761,0.0001127673,0.000224422,0.0001613834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005324198,"about_ca_system_score_gemma":0.00004257196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001411988,"about_ca_topic_score_gemma":0.00000739227,"domain_scores_codex":[0.998685,0.000007522922,0.0002276505,0.0004247986,0.0002774252,0.0003776107],"domain_scores_gemma":[0.9991533,0.0001944213,0.00009825161,0.0003135304,0.00003233804,0.0002081399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002921284,0.0001560587,0.00624952,0.00009130583,0.00006541931,0.00006958518,0.0008811567,2.704347e-7,0.9730429,0.00002203437,0.004244832,0.01514769],"study_design_scores_gemma":[0.000405409,0.00001226889,0.001189783,0.0000758953,0.00001766448,0.0002097125,0.0003858708,0.00002171735,0.9756733,0.0001878118,0.02151212,0.0003084126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9601955,0.001514621,0.00000267154,0.0004811976,0.00006635226,0.0000432116,0.000004846919,0.000159778,0.03753181],"genre_scores_gemma":[0.9957217,0.0005844783,0.0002209248,0.0001657996,0.000276056,0.00002158467,0.00001192093,0.00004492557,0.002952589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03552621,"threshold_uncertainty_score":0.9776495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342293086868059,"score_gpt":0.2100451813010931,"score_spread":0.1966222504324125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}