{"id":"W2102229168","doi":"10.1128/jvi.80.3.1110-1120.2006","title":"Activated MEK Suppresses Activation of PKR and Enables Efficient Replication and In Vivo Oncolysis by Δγ <sub>1</sub> 34.5 Mutants of Herpes Simplex Virus 1","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Cancer Institute; National Institutes of Health","keywords":"Protein kinase R; Biology; Herpes simplex virus; Mutant; Oncolytic virus; Cell culture; Virology; Viral replication; Virus; Protein kinase A; Molecular biology; Kinase; Cell biology; Gene; Mitogen-activated protein kinase kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008831867,0.0003074563,0.0001402114,0.0001575064,0.00008898118,0.0002467111,0.0001648748,0.0001186725,0.0008830871],"category_scores_gemma":[0.0001033699,0.0001487193,0.0001407966,0.00007193466,0.0002065946,0.0001252378,0.000148847,0.0004031653,0.0001924913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939003,"about_ca_system_score_gemma":0.0001790333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006079429,"about_ca_topic_score_gemma":0.0007730607,"domain_scores_codex":[0.9998786,0.00002119388,0.00001510311,0.00001785272,0.00003155657,0.0000355146],"domain_scores_gemma":[0.9999391,0.0000132365,0.00001868708,0.00000968233,0.000003931298,0.00001537615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008249989,0.00001768842,0.0002101788,0.00001004985,0.000002956168,0.00002128114,0.000009864884,0.0001385844,0.9986946,0.000174362,0.00001326,0.0006246375],"study_design_scores_gemma":[0.000007800709,0.0001164293,0.001013065,0.000002030629,0.000005999576,0.000146676,0.00001008013,0.0007560987,0.9972622,0.00002652262,0.0006510955,0.000001939163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986511,0.0001469433,0.0005646124,0.00001538372,0.000004502923,0.000005453315,0.00008515106,0.00001951285,0.0005074046],"genre_scores_gemma":[0.9983661,0.0001064838,0.0007320069,0.000006985644,0.000001124933,0.000005610254,0.0001165459,0.000006491397,0.0006587732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008830871,"threshold_uncertainty_score":0.002954185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008997031363602435,"score_gpt":0.275104345561227,"score_spread":0.2661073141976246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}