{"id":"W2102229168","doi":"10.1128/jvi.80.3.1110-1120.2006","title":"Activated MEK Suppresses Activation of PKR and Enables Efficient Replication and In Vivo Oncolysis by Δγ <sub>1</sub> 34.5 Mutants of Herpes Simplex Virus 1","year":2006,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Cancer Institute; National Institutes of Health","keywords":"Protein kinase R; Biology; Herpes simplex virus; Mutant; Oncolytic virus; Cell culture; Virology; Viral replication; Virus; Protein kinase A; Molecular biology; Kinase; Cell biology; Gene; Mitogen-activated protein kinase kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004490132,0.0001069717,0.0002788023,0.0001707705,0.00002845451,0.000006922623,0.0001089685,0.0001611322,0.00001134081],"category_scores_gemma":[0.0001340702,0.00009596459,0.00004421473,0.0001457305,0.000161675,0.000009785987,0.00004886867,0.00009297318,9.970705e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002400959,"about_ca_system_score_gemma":0.00007226571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006956923,"about_ca_topic_score_gemma":0.0001297319,"domain_scores_codex":[0.998839,0.0001889365,0.0004468707,0.000202783,0.0001592959,0.0001630862],"domain_scores_gemma":[0.9990516,0.00008263027,0.0004591717,0.0001976522,0.0001660714,0.00004287323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00349435,0.0002698897,0.0009901221,0.00002554818,0.00006735385,0.000002108335,0.00003541949,0.001007977,0.9847164,0.000002631093,0.0002498134,0.009138456],"study_design_scores_gemma":[0.001136763,0.001610117,0.005850376,0.00001584992,0.00001948115,0.00001968984,0.00004382959,0.0001661874,0.9904228,0.00008067528,0.0005623323,0.00007191146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985473,0.000879398,0.0001647974,0.0002245563,0.00001387627,0.0001199405,0.00002901204,0.000001536864,0.00001963482],"genre_scores_gemma":[0.9989359,0.0008791006,0.00006347228,0.00004399212,0.00004049031,0.000004384533,0.00001317592,0.00001256872,0.000006932179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009066544,"threshold_uncertainty_score":0.3913323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008997031363602435,"score_gpt":0.275104345561227,"score_spread":0.2661073141976246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}