{"id":"W2102246235","doi":"10.1124/pr.111.005603","title":"The Expanding Roles of Gβγ Subunits in G Protein–Coupled Receptor Signaling and Drug Action","year":2013,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Heterotrimeric G protein; G protein; Biology; G protein-coupled receptor; Protein subunit; Cell biology; Gene isoform; Signal transduction; Action (physics); Computational biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001543719,0.0003598974,0.001047072,0.00007074941,0.0001329671,0.00004246666,0.0002699947,0.0002508896,0.0001118224],"category_scores_gemma":[0.0004160353,0.0002067037,0.0003041277,0.0002237287,0.0001174401,0.000008135499,0.0001686663,0.0003420325,0.00002002209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003746524,"about_ca_system_score_gemma":0.00007915489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005590535,"about_ca_topic_score_gemma":0.000006504768,"domain_scores_codex":[0.9972118,0.0009628993,0.0009610151,0.0004320057,0.0001441398,0.0002881972],"domain_scores_gemma":[0.9987942,0.0001205961,0.0007162207,0.0002017613,0.0000625922,0.0001046321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001932732,0.00003485781,0.00000175032,0.003047453,0.00004402918,9.792022e-7,0.000009373918,0.000001586697,0.125637,0.00002756089,0.0002829406,0.8708931],"study_design_scores_gemma":[0.0002202631,0.0000520406,6.008613e-7,0.003571873,0.0001450452,0.000004431231,0.00001317166,0.00002324871,0.01436604,0.00002644017,0.9813358,0.000241108],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004945328,0.9916177,0.00008073592,0.00003502261,0.00008761399,0.003178097,0.000006503698,0.000009544775,0.00003946272],"genre_scores_gemma":[0.001118282,0.9966571,0.0003116384,0.00003634157,0.0002280232,0.001284978,0.00007815722,0.00002531787,0.0002602082],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9810528,"threshold_uncertainty_score":0.8429131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09254266670039363,"score_gpt":0.3860618936487005,"score_spread":0.2935192269483069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}