{"id":"W2102270991","doi":"10.1210/endo.143.6.8749","title":"Genomic and Nongenomic Mechanisms of Nitric Oxide Synthesis Induction in Human Endothelial Cells by a Fourth-Generation Selective Estrogen Receptor Modulator","year":2002,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Enos; Selective estrogen receptor modulator; Raloxifene; Endocrinology; Internal medicine; Estrogen receptor; Estrogen; Ovariectomized rat; Nitric oxide; Biology; Protein kinase B; Nitric Oxide Synthase Type III; Umbilical vein; Nitric oxide synthase; Medicine; Signal transduction; In vitro; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007101244,0.0001821633,0.0002326872,0.0001466679,0.00007113507,0.000007987886,0.0001051974,0.000242125,0.00003102629],"category_scores_gemma":[0.00002940209,0.0001900888,0.0000621447,0.00009660731,0.00008108237,0.000006221595,0.0000620383,0.000165405,0.00001480427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004845697,"about_ca_system_score_gemma":0.00001774483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008844231,"about_ca_topic_score_gemma":0.000008072378,"domain_scores_codex":[0.998799,0.0001639223,0.0002622425,0.0003963858,0.00006425782,0.00031417],"domain_scores_gemma":[0.9995847,0.0000178368,0.0001250823,0.0001838895,0.00003037425,0.00005810305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003912744,0.00008910579,0.0006736664,0.000007374057,0.00008649127,0.00000366834,0.00003536097,0.000088769,0.9966823,0.0002051856,0.0003820003,0.001706966],"study_design_scores_gemma":[0.000660551,0.0002979672,0.0005140005,0.000004104479,0.00003314029,0.00006318386,0.00002592215,0.0003053864,0.9975494,0.0000622165,0.0003149703,0.0001692046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976989,0.001354228,0.0003608736,0.00002874892,0.0001010959,0.0002830414,0.00004089746,0.00001267058,0.0001195386],"genre_scores_gemma":[0.9980912,0.0006769428,0.0007993727,0.00002468817,0.0001078147,0.00005887227,0.00003996623,0.00002983396,0.0001713426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001537762,"threshold_uncertainty_score":0.7751598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008514077002044712,"score_gpt":0.2056694161745864,"score_spread":0.1971553391725417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}