{"id":"W2102270991","doi":"10.1210/endo.143.6.8749","title":"Genomic and Nongenomic Mechanisms of Nitric Oxide Synthesis Induction in Human Endothelial Cells by a Fourth-Generation Selective Estrogen Receptor Modulator","year":2002,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Enos; Selective estrogen receptor modulator; Raloxifene; Endocrinology; Internal medicine; Estrogen receptor; Estrogen; Ovariectomized rat; Nitric oxide; Biology; Protein kinase B; Nitric Oxide Synthase Type III; Umbilical vein; Nitric oxide synthase; Medicine; Signal transduction; In vitro; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855949,0.0001607177,0.000114813,0.0001307783,0.00009498752,0.0001411141,0.0001464937,0.0001226933,0.0007364611],"category_scores_gemma":[0.0001118461,0.00009047336,0.0001458076,0.00009558913,0.0001216016,0.00008348194,0.0001123147,0.0002012266,0.0001523837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001347327,"about_ca_system_score_gemma":0.0001395092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00040551,"about_ca_topic_score_gemma":0.0005364336,"domain_scores_codex":[0.9999111,0.00003167334,0.000006005046,0.00001687543,0.00001733169,0.00001707015],"domain_scores_gemma":[0.9999545,0.00001143081,0.00001148098,0.000007617345,0.000006503765,0.000008439813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003054749,0.00007680659,0.0004885946,0.00003456399,0.000006833272,0.0001087162,0.00002101731,0.00006554541,0.9944084,0.0002326864,0.00003809883,0.004213225],"study_design_scores_gemma":[0.00008115639,0.00143204,0.02227632,0.00001020657,0.00003864909,0.0005260747,0.00005482943,0.0006885043,0.970266,0.0001797426,0.004439626,0.00000676341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858202,0.007396355,0.004168951,0.0001295873,0.00003655958,0.00002544615,0.0001822677,0.00002890794,0.002211682],"genre_scores_gemma":[0.9928591,0.003084775,0.001967772,0.00007059343,0.0000178637,0.00003727915,0.0003315314,0.000003274053,0.001627822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007364611,"threshold_uncertainty_score":0.002463758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008514077002044712,"score_gpt":0.2056694161745864,"score_spread":0.1971553391725417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}