{"id":"W2102273841","doi":"10.1093/abbs/gmr119","title":"OxLDL up-regulates Niemann&amp;ndash;Pick type C1 expression through ERK1/2/COX-2/PPAR&amp;alpha;-signaling pathway in macrophages","year":2012,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"NPC1; Small interfering RNA; Endosome; Cell biology; Chemistry; Peroxisome proliferator-activated receptor; Signal transduction; Intracellular; Kinase; Phosphorylation; Protein kinase A; Lysosome; Transfection; Receptor; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00018174,0.0004504021,0.0004234218,0.0003555476,0.0002502099,0.0003046955,0.0001255097,0.0002430849,0.00101721],"category_scores_gemma":[0.00009521967,0.0002338427,0.0003909302,0.000229438,0.000249939,0.0002565704,0.0002830526,0.0005969253,0.000335827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002470152,"about_ca_system_score_gemma":0.0002627446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005675807,"about_ca_topic_score_gemma":0.0007471677,"domain_scores_codex":[0.9998544,0.00002322615,0.00001764555,0.00002211032,0.00003116453,0.00005147093],"domain_scores_gemma":[0.9999053,0.000008177999,0.00003289535,0.000007693796,0.00001621219,0.00002966309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001655114,0.0002062125,0.0007477285,0.0002687913,0.00001686974,0.0003120396,0.00007251924,0.00008016774,0.9940398,0.0001000171,0.0001335754,0.002367346],"study_design_scores_gemma":[0.0001800963,0.0008575553,0.02553596,0.0000299368,0.00007208405,0.0006245458,0.0001846688,0.001685948,0.9661453,0.0002094316,0.004451853,0.00002252841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99159,0.005387125,0.001093409,0.0001977236,0.00007268157,0.00004433861,0.0003570227,0.00005404585,0.001203659],"genre_scores_gemma":[0.9895896,0.003529912,0.001831742,0.0001306547,0.00004187509,0.0001227311,0.0004956623,0.0000156152,0.00424214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101721,"threshold_uncertainty_score":0.003402889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03002781084954123,"score_gpt":0.302180598175337,"score_spread":0.2721527873257957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}