{"id":"W2102273841","doi":"10.1093/abbs/gmr119","title":"OxLDL up-regulates Niemann&amp;ndash;Pick type C1 expression through ERK1/2/COX-2/PPAR&amp;alpha;-signaling pathway in macrophages","year":2012,"lang":"en","type":"article","venue":"Acta Biochimica et Biophysica Sinica","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"NPC1; Small interfering RNA; Endosome; Cell biology; Chemistry; Peroxisome proliferator-activated receptor; Signal transduction; Intracellular; Kinase; Phosphorylation; Protein kinase A; Lysosome; Transfection; Receptor; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004169348,0.0007385397,0.0006694687,0.0001460478,0.0002397558,0.0001212022,0.0007839386,0.0006856897,0.0001681965],"category_scores_gemma":[0.0003268863,0.000661892,0.0003076179,0.0005913405,0.0003209673,0.0001033776,0.0006182055,0.0005979335,0.0002571696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000812841,"about_ca_system_score_gemma":0.0002003648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006080593,"about_ca_topic_score_gemma":0.00001912673,"domain_scores_codex":[0.9961732,0.0003444861,0.0007917564,0.001089742,0.0004333308,0.001167504],"domain_scores_gemma":[0.9976739,0.0001114985,0.0004181795,0.001284098,0.0001789852,0.0003332924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003856814,0.0006346725,0.0005274946,0.00004767689,0.0001232132,0.000001526057,0.0006231815,0.000008908776,0.9919878,0.00006478286,0.005325445,0.0002695849],"study_design_scores_gemma":[0.0008475354,0.0002077967,0.0005132061,0.0001250017,0.00002920195,0.00001439375,0.00007328725,0.000002850938,0.9232786,0.0001812695,0.07395793,0.0007689467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958249,0.001235146,0.0000434872,0.000769016,0.0009600879,0.0004737958,0.00009636737,0.0001117216,0.0004855063],"genre_scores_gemma":[0.9922127,0.0005507183,0.003255863,0.0007587339,0.0008914208,0.0000686985,0.0008165324,0.0001566794,0.00128866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06870925,"threshold_uncertainty_score":0.9995832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03002781084954123,"score_gpt":0.302180598175337,"score_spread":0.2721527873257957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}