{"id":"W2102284823","doi":"10.1016/j.bmc.2010.11.020","title":"3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the α2-adrenoceptor compared to the imidazoline I1 receptor","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Imidazoline receptor; Selectivity; Indazole; Clonidine; Ligand (biochemistry); Stereochemistry; Adrenergic receptor; Agonist; Receptor; Pharmacology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002220756,0.0003700568,0.0004187749,0.0001489248,0.0002693417,0.0002948014,0.0005414331,0.0003871239,0.002890805],"category_scores_gemma":[0.0002124261,0.0001301298,0.000119794,0.0002934126,0.0002073901,0.000234076,0.0001814216,0.00054243,0.0006335489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005585917,"about_ca_system_score_gemma":0.0002846208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007791753,"about_ca_topic_score_gemma":0.002336524,"domain_scores_codex":[0.999854,0.00002602093,0.000007213007,0.00002234813,0.0000249288,0.00006541262],"domain_scores_gemma":[0.9999368,0.0000135455,0.00001774916,0.000005158955,0.00001008477,0.0000165791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001081374,0.0001081362,0.0004132062,0.00020052,0.00001140319,0.0003779643,0.00009680758,0.0007598966,0.9679338,0.002421123,0.001084854,0.02551084],"study_design_scores_gemma":[0.001279663,0.003727204,0.005224911,0.00005454003,0.00008575345,0.0025393,0.0001094507,0.00600128,0.9476197,0.0004663861,0.03283485,0.00005704164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498356,0.009172989,0.01271927,0.0009235205,0.0002270376,0.000145703,0.0003839322,0.0004043483,0.02618749],"genre_scores_gemma":[0.9845889,0.002690086,0.005879273,0.000323165,0.00006369739,0.00009881011,0.0003372351,0.00002294543,0.005995806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002890805,"threshold_uncertainty_score":0.009670675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008582338098737385,"score_gpt":0.2338571260442292,"score_spread":0.2252747879454919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}