{"id":"W2102296441","doi":"10.1096/fj.12-205229","title":"Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment","year":2012,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Cathepsin; Cathepsin S; Cathepsin L1; Cathepsin B; Cystatin; Cathepsin D; Cathepsin C; Cathepsin O; Cathepsin L; Chemistry; Cathepsin E; Cathepsin A; Extracellular; Cancer cell; Proteolysis; Biochemistry; Molecular biology; Cystatin C; Cathepsin H; Biology; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005535497,0.0000780898,0.00007208205,0.00001396629,0.00007568956,0.00001106685,0.0002191071,0.00003938236,0.00007974178],"category_scores_gemma":[0.000007382851,0.00004085154,0.00006240821,0.00004205044,0.00004935874,0.000004732614,0.0000377984,0.0001355457,0.000004630591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001639319,"about_ca_system_score_gemma":0.00002628698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007109553,"about_ca_topic_score_gemma":0.000007839432,"domain_scores_codex":[0.9992886,0.0001584142,0.0001551833,0.00006549649,0.0001353214,0.0001969571],"domain_scores_gemma":[0.9996525,0.000005699482,0.000115014,0.0001725929,0.00001258354,0.00004161114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004137259,0.00008727753,0.002094801,0.000003232032,0.00002205398,7.403915e-7,0.0003170751,0.000007196053,0.9930971,0.00001009748,0.003266068,0.001053021],"study_design_scores_gemma":[0.0002424662,0.00005824679,0.001271767,0.00001574998,0.00001990026,0.0001901074,0.0002940679,0.000004307894,0.9955384,0.00004830493,0.002258548,0.00005813675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955511,0.00284143,0.0003847483,0.0008591799,0.00006610394,0.000162696,0.00006074187,7.590314e-7,0.00007322529],"genre_scores_gemma":[0.9987559,0.000353533,0.0001016025,0.0003608321,0.0002698853,0.00002945069,0.000007322873,0.000007845204,0.0001135675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003204845,"threshold_uncertainty_score":0.1665877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006806375037433232,"score_gpt":0.2250405665294619,"score_spread":0.2182341914920286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}