{"id":"W2102296441","doi":"10.1096/fj.12-205229","title":"Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment","year":2012,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale","keywords":"Cathepsin; Cathepsin S; Cathepsin L1; Cathepsin B; Cystatin; Cathepsin D; Cathepsin C; Cathepsin O; Cathepsin L; Chemistry; Cathepsin E; Cathepsin A; Extracellular; Cancer cell; Proteolysis; Biochemistry; Molecular biology; Cystatin C; Cathepsin H; Biology; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475809,0.0002640374,0.0002323665,0.0002593357,0.0001731803,0.0006245438,0.0001096558,0.0003105987,0.0008797479],"category_scores_gemma":[0.0001650607,0.000130094,0.0002386912,0.0002201193,0.0001940534,0.0002541688,0.0002504268,0.0003845745,0.0003219923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003947092,"about_ca_system_score_gemma":0.0002207145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049185,"about_ca_topic_score_gemma":0.0007320142,"domain_scores_codex":[0.9998937,0.0000164213,0.000006422633,0.00003060901,0.00002752717,0.00002529965],"domain_scores_gemma":[0.9999381,0.000009700788,0.00001371826,0.000006583579,0.00001413951,0.00001772133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059628,0.00001672636,0.002386139,0.00007791854,0.00001636998,0.0001833504,0.00001841869,0.00008392525,0.9924839,0.00008310506,0.0001449565,0.004299252],"study_design_scores_gemma":[0.0000279466,0.000267055,0.08093888,0.00002866029,0.00005477307,0.003110698,0.0001338407,0.002711179,0.9032466,0.0003542871,0.009105756,0.00002028081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786404,0.01624315,0.00283466,0.0003280782,0.00005117495,0.00001813504,0.0004452812,0.00005904548,0.00138006],"genre_scores_gemma":[0.9929246,0.003772546,0.001266633,0.00009313838,0.00001314741,0.00001094798,0.0003602125,0.000008480739,0.001550298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049185,"threshold_uncertainty_score":0.002942979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006806375037433232,"score_gpt":0.2250405665294619,"score_spread":0.2182341914920286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}