{"id":"W2102296765","doi":"10.1101/gad.170605.111","title":"Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Ellison Medical Foundation","keywords":"Biology; Ubiquitin ligase; Ubiquitin; DNA damage; Histone deacetylase 2; Histone; Acetylation; Cell biology; Null cell; Cancer research; Apoptosis; Histone deacetylase; DNA repair; Epigenetics; DNA; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093678,0.00025376,0.0002438286,0.0002084279,0.0001840341,0.0004219572,0.0001854403,0.0002643648,0.001649821],"category_scores_gemma":[0.0001292879,0.0002213121,0.0002355698,0.00009948297,0.0002998873,0.0002564352,0.0002486072,0.0004360896,0.0004965405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649072,"about_ca_system_score_gemma":0.0001403291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000297025,"about_ca_topic_score_gemma":0.0005719463,"domain_scores_codex":[0.9998735,0.00001612917,0.00001378303,0.00003461816,0.00002933864,0.00003257501],"domain_scores_gemma":[0.9998772,0.00001807685,0.000044761,0.00001971689,0.00001230831,0.00002791594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008139436,0.00000820676,0.0002439623,0.00001034057,0.000002577686,0.00003568378,0.000004311744,0.00002177585,0.9988733,0.000107426,0.00002037243,0.0005905929],"study_design_scores_gemma":[0.00000811821,0.00004990999,0.003835013,0.000002149799,0.000005232276,0.0002154489,0.00001145126,0.0003376157,0.9942966,0.00005694369,0.001179654,0.000001914976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99102,0.002250937,0.004323238,0.0001499517,0.00003134366,0.00001643068,0.0004309043,0.0001350601,0.001642099],"genre_scores_gemma":[0.996219,0.0004599116,0.001151395,0.00004408081,0.000005098998,0.00001094368,0.000312698,0.00002251337,0.001774368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001649821,"threshold_uncertainty_score":0.005519211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294225975028963,"score_gpt":0.2434425675153639,"score_spread":0.2305003077650743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}