{"id":"W2102296765","doi":"10.1101/gad.170605.111","title":"Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Institutes of Health; Ellison Medical Foundation","keywords":"Biology; Ubiquitin ligase; Ubiquitin; DNA damage; Histone deacetylase 2; Histone; Acetylation; Cell biology; Null cell; Cancer research; Apoptosis; Histone deacetylase; DNA repair; Epigenetics; DNA; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004583916,0.0001280819,0.0001027815,0.00008189233,0.0001253519,0.00001101274,0.0001351237,0.00008700021,0.00001478181],"category_scores_gemma":[0.0001521249,0.0001052994,0.00002722827,0.000130197,0.0000915366,0.000005135009,0.0001482246,0.00004781561,0.000009580944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004228491,"about_ca_system_score_gemma":0.0001451787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002652024,"about_ca_topic_score_gemma":0.00003353157,"domain_scores_codex":[0.9989387,0.0001236898,0.0002624022,0.0002688882,0.0001975258,0.0002088306],"domain_scores_gemma":[0.9994689,0.00001942453,0.00007299214,0.000207938,0.0001438426,0.00008696913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002943663,0.00003030211,0.0005913907,0.00001484506,0.00001891182,0.000001045968,0.0009036541,0.000002700501,0.9712593,0.000002883073,0.001315576,0.02556501],"study_design_scores_gemma":[0.0002049998,0.0001623165,0.01127202,0.00001343539,0.000005104418,0.00001230385,0.0001558741,0.000005433158,0.9607207,0.00000706426,0.02731171,0.0001290436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984645,0.0005212385,0.0004147437,0.00009732016,0.0001240947,0.0002846783,0.000006831203,0.000009441058,0.00007718838],"genre_scores_gemma":[0.9944652,0.00004943238,0.004847457,0.00005496069,0.00005018989,0.00006949998,0.00003110162,0.00001878164,0.0004133536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02599613,"threshold_uncertainty_score":0.4293984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294225975028963,"score_gpt":0.2434425675153639,"score_spread":0.2305003077650743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}