{"id":"W2102297470","doi":"10.1093/protein/14.9.669","title":"N-terminal portion acts as an initiator of the inactivation of pepsin at neutral pH","year":2001,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pepsin; Chemistry; Zymogen; Enzyme; Mutant; Protease; Peptide; Dissociation (chemistry); Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002576094,0.000296251,0.0002121882,0.00008430064,0.0001123342,0.0002681866,0.0001852113,0.0002158982,0.0004807929],"category_scores_gemma":[0.000212867,0.0001274038,0.0001971991,0.00009972108,0.0002755483,0.0002372744,0.0002029564,0.0003857171,0.0002659335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001186546,"about_ca_system_score_gemma":0.0001124376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001275963,"about_ca_topic_score_gemma":0.0001643758,"domain_scores_codex":[0.9998655,0.00003385913,0.00001490562,0.00002610967,0.00003568259,0.00002398414],"domain_scores_gemma":[0.9998005,0.00005651124,0.00005731971,0.0000274862,0.00002208399,0.00003616391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002792729,0.000009291991,0.0001274166,0.000009975899,0.000001146053,0.00002949521,0.000006585503,0.00003097351,0.9992579,0.00003240976,0.000002979672,0.0004638736],"study_design_scores_gemma":[0.000004280961,0.0001181628,0.0012744,0.000002282246,0.000004536866,0.000157953,0.000006012641,0.0002537666,0.9976358,0.00001268193,0.0005284455,0.000001657705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933148,0.0003539319,0.00543114,0.00002977782,0.000008689756,0.00002340053,0.00003044551,0.00001958868,0.0007882267],"genre_scores_gemma":[0.9919081,0.0002919642,0.0064678,0.0000293791,0.000005307,0.00001514175,0.0001350745,0.00001564107,0.001131477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004807929,"threshold_uncertainty_score":0.001608431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116265642940884,"score_gpt":0.2060745927862941,"score_spread":0.1944480284922057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}