{"id":"W2102297522","doi":"10.1200/jco.2005.04.044","title":"Randomized Phase III Study of Matrix Metalloproteinase Inhibitor BMS-275291 in Combination With Paclitaxel and Carboplatin in Advanced Non-Small-Cell Lung Cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Carboplatin; Lung cancer; Internal medicine; Rash; Neutropenia; Interim analysis; Clinical endpoint; Toxicity; Febrile neutropenia; Chemotherapy; Paclitaxel; Surgery; Gastroenterology; Phases of clinical research; Oncology; Clinical trial; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00234608,0.002231828,0.003710962,0.0007093307,0.00062289,0.001146616,0.001379534,0.001739821,0.006623683],"category_scores_gemma":[0.001520554,0.0009189738,0.001415426,0.0007397559,0.001293223,0.0007612098,0.0003810674,0.002879054,0.001263248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002103683,"about_ca_system_score_gemma":0.004334549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005722786,"about_ca_topic_score_gemma":0.0203628,"domain_scores_codex":[0.9992834,0.0003946686,0.00003303965,0.00009480587,0.00007234963,0.0001219225],"domain_scores_gemma":[0.9991406,0.0001344001,0.000191517,0.00005349263,0.00006513452,0.0004147686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9580778,0.0150269,0.001019366,0.0007331555,0.001014796,0.0000704223,0.00005042223,0.0004747994,0.00455878,0.0001452312,0.002812531,0.01601592],"study_design_scores_gemma":[0.9683898,0.0295736,0.0009136429,0.00001140974,0.0001624323,0.00002085579,0.000007696103,0.000172619,0.0001974277,0.00004922738,0.0004950824,0.000006187508],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598696,0.007319341,0.001106426,0.001567116,0.0007506371,0.02084217,0.004400764,0.0002910157,0.003853025],"genre_scores_gemma":[0.9500048,0.006054345,0.004292424,0.00274453,0.00062513,0.02244434,0.004893172,0.00007162905,0.008869647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006623683,"threshold_uncertainty_score":0.02215844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06504719039632889,"score_gpt":0.451683232016112,"score_spread":0.3866360416197832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}