{"id":"W2102297522","doi":"10.1200/jco.2005.04.044","title":"Randomized Phase III Study of Matrix Metalloproteinase Inhibitor BMS-275291 in Combination With Paclitaxel and Carboplatin in Advanced Non-Small-Cell Lung Cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Carboplatin; Lung cancer; Internal medicine; Rash; Neutropenia; Interim analysis; Clinical endpoint; Toxicity; Febrile neutropenia; Chemotherapy; Paclitaxel; Surgery; Gastroenterology; Phases of clinical research; Oncology; Clinical trial; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01759815,0.0002334114,0.002893242,0.0001832449,0.00003394587,0.00000707135,0.0002157124,0.0003283533,0.00002104791],"category_scores_gemma":[0.004074951,0.0001734224,0.000262435,0.0001952787,0.0001575834,0.00003838915,0.00009577575,0.0006028028,5.268469e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001703184,"about_ca_system_score_gemma":0.004373703,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01638235,"about_ca_topic_score_gemma":0.2705794,"domain_scores_codex":[0.9906716,0.002750389,0.005418375,0.0003846975,0.0005393953,0.0002355603],"domain_scores_gemma":[0.9938608,0.001068491,0.004084576,0.0001762234,0.0006108109,0.0001991097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6927986,0.06194012,0.06603688,0.000228196,0.003023888,0.0003397553,0.00103858,0.004346918,0.1361349,0.00008842452,0.0008843893,0.03313945],"study_design_scores_gemma":[0.9373431,0.02768949,0.006087844,0.0002434495,0.00071192,0.00001135007,0.001060821,0.001413848,0.02438562,0.00007670413,0.000647725,0.0003281018],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943183,0.001622539,0.0001727282,0.0003332977,0.0007070627,0.002745929,0.0000244267,0.000001525634,0.0000741621],"genre_scores_gemma":[0.9972064,0.0006684517,0.001127501,0.0001434825,0.0005795757,0.0001961026,0.000007471427,0.00001708098,0.00005392752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2541971,"threshold_uncertainty_score":0.9901677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06504719039632889,"score_gpt":0.451683232016112,"score_spread":0.3866360416197832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}