{"id":"W2102396209","doi":"10.1093/cvr/cvr159","title":"Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1–Smad signalling","year":2011,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"National Heart, Lung, and Blood Institute; Fundamental Research Funds for the Central Universities; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Internal medicine; Endocrinology; Muscle hypertrophy; Angiotensin II; Protein kinase B; GSK3B; Medicine; Cardiac function curve; Pressure overload; Biology; Fibrosis; Heart failure; Signal transduction; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00440825,0.000472089,0.001582285,0.0006034105,0.0006776226,0.0001545549,0.0002739102,0.0004246577,0.00007334227],"category_scores_gemma":[0.0001677581,0.0003966554,0.002514414,0.0007463131,0.0004207686,0.0002078872,0.0005267326,0.001250279,0.0001309313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424243,"about_ca_system_score_gemma":0.0001411921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004276654,"about_ca_topic_score_gemma":4.696539e-7,"domain_scores_codex":[0.9936513,0.0008538497,0.0005598299,0.001292385,0.002374503,0.001268133],"domain_scores_gemma":[0.9967215,0.0002554165,0.00006801458,0.001534383,0.0007873152,0.0006333733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007081317,0.0002021424,0.0187922,0.0007188773,0.005779956,0.0003270712,0.00322694,0.0002780602,0.8657658,0.0001329502,0.002680658,0.1013872],"study_design_scores_gemma":[0.008419435,0.001558396,0.086864,0.005618151,0.003551663,0.000717958,0.006687521,0.003670025,0.6185533,0.0007494536,0.2601372,0.003472877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8938712,0.09672853,0.000852276,0.00006535104,0.0005673353,0.001293586,0.00002471756,0.0001263294,0.006470663],"genre_scores_gemma":[0.9890547,0.00651271,0.002224975,0.00002320119,0.001587991,0.0001004424,0.00004891291,0.0001622138,0.0002848274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2574566,"threshold_uncertainty_score":0.9998485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1099446168302775,"score_gpt":0.3039568973501095,"score_spread":0.194012280519832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}