{"id":"W2102412293","doi":"10.1093/hmg/dds132","title":"Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; Chromatin immunoprecipitation; Huntingtin; Transcription factor; Regulation of gene expression; Gene expression; Cell biology; Gene; Genetics; Mutant; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003238752,0.0001969106,0.0001784051,0.0001731971,0.0001549724,0.00003938146,0.0003608796,0.00005715153,0.00003471556],"category_scores_gemma":[0.0001233759,0.0001913158,0.0001945719,0.0003190735,0.0001408191,0.0001006056,0.00001860186,0.0001168818,0.0000016146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003200577,"about_ca_system_score_gemma":0.00006395904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006393027,"about_ca_topic_score_gemma":0.000006967683,"domain_scores_codex":[0.9979386,0.0003014067,0.0005874407,0.0004204558,0.0003683747,0.0003836781],"domain_scores_gemma":[0.99913,0.00008708236,0.0001574115,0.0004587121,0.00007756636,0.00008926784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004944341,0.0004466655,0.00403908,0.00005953784,0.000004109052,5.417875e-7,0.0009545449,0.002012576,0.9618722,0.03039478,0.000009198565,0.0001573322],"study_design_scores_gemma":[0.000548818,0.00004683645,0.3830879,0.00003558678,0.00002930345,7.84908e-7,0.00003377273,0.0002794373,0.6068005,0.008880997,0.0001196553,0.0001363903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864937,0.0009174696,0.009496795,0.0009632896,0.00004517697,0.001802888,0.0001914875,0.00001449181,0.00007467683],"genre_scores_gemma":[0.9968693,0.00001026644,0.001496112,0.0006198002,0.00005831364,0.0008236713,0.00006457347,0.0000356412,0.00002227332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3790488,"threshold_uncertainty_score":0.7801632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06220985713117404,"score_gpt":0.313327866777158,"score_spread":0.2511180096459839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}