{"id":"W2102416906","doi":"10.1016/j.jalz.2014.05.1757","title":"Convergent genetic and expression data implicate immunity in Alzheimer's disease","year":2014,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; McGill University and Génome Québec Innovation Centre; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institutes of Health; Alzheimer’s Research UK; Fédération pour la Recherche sur le Cerveau; Erasmus Medisch Centrum; Medical Research Council; Labex; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Alzheimer's Society; Wellcome Trust; National Institute on Aging; Alzheimer's Association; Wellcome; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease","keywords":"Biology; Genome-wide association study; Disease; Endocytosis; Computational biology; Biological pathway; Genetic association; Immune system; Gene; Proteasome; Genetics; Functional genomics; Ubiquitin; Genomics; Gene expression; Bioinformatics; Genome; Medicine; Cell; Genotype; Internal medicine; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003253508,0.0003230119,0.0003705022,0.0001590714,0.0001776375,0.00005363368,0.0003991252,0.00007920185,0.0003771631],"category_scores_gemma":[0.000052983,0.0002778507,0.00007540677,0.000188908,0.0001835081,0.0002121269,0.0007949066,0.0002238544,0.0002021604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008720907,"about_ca_system_score_gemma":0.0001591153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002687317,"about_ca_topic_score_gemma":0.00002288136,"domain_scores_codex":[0.997489,0.0002269449,0.0004213868,0.0007675639,0.0004717731,0.0006233685],"domain_scores_gemma":[0.9970226,0.00008132702,0.0001033037,0.0017328,0.0000737435,0.0009862785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001441479,0.001905333,0.7626396,0.00004634014,0.08869164,0.0004110395,0.0001337879,0.000006464173,0.001467239,0.0002014867,0.007080238,0.1359753],"study_design_scores_gemma":[0.00450029,0.0002642217,0.944613,0.0001213499,0.03829344,0.00002544643,0.00003820543,0.002543929,0.004197453,0.0006777631,0.004276716,0.0004481411],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4301087,0.5665347,0.0001206312,0.0008351128,0.0001472267,0.001342115,0.0001511029,0.0001033115,0.0006570966],"genre_scores_gemma":[0.9960662,0.001439544,0.001165177,0.0003205294,0.00009363346,0.0001100851,0.0007528117,0.00005044669,0.00000153666],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5659575,"threshold_uncertainty_score":0.9999674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0539128413635623,"score_gpt":0.3278448709370705,"score_spread":0.2739320295735082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}