{"id":"W2102416906","doi":"10.1016/j.jalz.2014.05.1757","title":"Convergent genetic and expression data implicate immunity in Alzheimer's disease","year":2014,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; McGill University and Génome Québec Innovation Centre; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institutes of Health; Alzheimer’s Research UK; Fédération pour la Recherche sur le Cerveau; Erasmus Medisch Centrum; Medical Research Council; Labex; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Institut National de la Santé et de la Recherche Médicale; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Alzheimer's Society; Wellcome Trust; National Institute on Aging; Alzheimer's Association; Wellcome; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease","keywords":"Biology; Genome-wide association study; Disease; Endocytosis; Computational biology; Biological pathway; Genetic association; Immune system; Gene; Proteasome; Genetics; Functional genomics; Ubiquitin; Genomics; Gene expression; Bioinformatics; Genome; Medicine; Cell; Genotype; Internal medicine; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267646,0.0003699076,0.0005088588,0.001483468,0.0004265041,0.0006362507,0.0002940833,0.000358972,0.002309793],"category_scores_gemma":[0.002315295,0.0001300089,0.0005770035,0.00152999,0.0007094456,0.0003679526,0.0006793037,0.0005983351,0.0002909235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004752623,"about_ca_system_score_gemma":0.0004829915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063951,"about_ca_topic_score_gemma":0.001424814,"domain_scores_codex":[0.999421,0.0001033806,0.000049281,0.0001986121,0.0001664876,0.00006130032],"domain_scores_gemma":[0.9976882,0.0009012891,0.0006975405,0.0002460446,0.0002892837,0.0001777147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001375216,0.0002802007,0.7288154,0.000491233,0.0009209996,0.0007531572,0.0003458393,0.002528904,0.225659,0.002321426,0.001043652,0.03546488],"study_design_scores_gemma":[0.00003802221,0.0002208842,0.9727656,0.00003536096,0.0004361246,0.001216186,0.0001380685,0.002750397,0.01568751,0.005363344,0.00132979,0.00001881182],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866168,0.001153638,0.007083552,0.0002717398,0.00001345687,0.00002788472,0.002749061,0.0001279998,0.001955813],"genre_scores_gemma":[0.9919531,0.0005025932,0.00506324,0.0001278305,0.00002180678,0.00002970593,0.001970727,0.00001821979,0.0003127679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309793,"threshold_uncertainty_score":0.007727027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0539128413635623,"score_gpt":0.3278448709370705,"score_spread":0.2739320295735082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}