{"id":"W2102441837","doi":"10.1128/mcb.24.18.7987-7997.2004","title":"Regulation of Human p53 Activity and Cell Localization by Alternative Splicing","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Mdm2; Alternative splicing; Cell growth; Tumor suppressor gene; Ectopic expression; Cell biology; RNA splicing; Cancer cell; Cancer research; Cell culture; Gene; Carcinogenesis; Gene isoform; Cancer; Genetics; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009205135,0.0001278509,0.000229434,0.00008133157,0.00005643155,0.000005440726,0.00003110909,0.0001613608,0.00001035549],"category_scores_gemma":[0.00001333966,0.0001256827,0.00004438611,0.0001007005,0.0001516136,0.00002405365,0.00004121353,0.000113319,0.000001148109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000448171,"about_ca_system_score_gemma":0.00002805802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003687406,"about_ca_topic_score_gemma":0.000008845365,"domain_scores_codex":[0.999266,0.0000583361,0.0001610616,0.0002860924,0.00008310577,0.0001454626],"domain_scores_gemma":[0.9995941,0.000007541104,0.0001058713,0.0001661288,0.0000536301,0.00007273857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004434922,0.00006721092,0.0004414009,0.00005782141,0.00003484902,0.00001334798,0.0001405124,0.0001347615,0.9963075,0.00150762,0.000008575125,0.001242069],"study_design_scores_gemma":[0.001731349,0.0005233974,0.0005094975,0.00004387033,0.00008107741,0.00002075062,0.00002061916,0.00048804,0.9945989,0.001682584,0.0001895722,0.0001103143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8104047,0.00145379,0.1872576,0.00008847695,0.00003343632,0.0002115544,0.00000672537,0.00001574205,0.000527981],"genre_scores_gemma":[0.999393,0.00007066335,0.0002233083,0.0001075352,0.00001920958,0.000005532252,0.0001235802,0.0000188721,0.00003823285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1889884,"threshold_uncertainty_score":0.5125193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006645717211949236,"score_gpt":0.2370251821817152,"score_spread":0.230379464969766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}