{"id":"W2102449842","doi":"10.1517/13543776.10.5.675","title":"Tyrosine phosphatases: cellular functions and therapeutic potential","year":2000,"lang":"en","type":"article","venue":"Expert Opinion on Therapeutic Patents","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada)","funders":"","keywords":"Protein tyrosine phosphatase; Tyrosine; Tyrosine phosphorylation; Receptor tyrosine kinase; Phosphorylation; Protein phosphorylation; Biochemistry; Tyrosine kinase; SH2 domain; Platelet-derived growth factor receptor; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Phosphatase; Chemistry; Biology; Signal transduction; Protein kinase A; Receptor; Growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001097749,0.000326225,0.0001993387,0.00005068975,0.000242816,0.0000607092,0.0002371262,0.0001672945,0.0006426517],"category_scores_gemma":[0.000009031864,0.0002909935,0.0001062637,0.0001116225,0.0001406639,0.00001052493,0.00005904525,0.0001184416,0.0001873696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001985165,"about_ca_system_score_gemma":0.00003629331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004906854,"about_ca_topic_score_gemma":8.805106e-7,"domain_scores_codex":[0.9983837,0.000107309,0.000264083,0.0006008878,0.0002534885,0.0003905169],"domain_scores_gemma":[0.9991513,0.00001157569,0.00007117585,0.0005711845,0.00004497369,0.000149796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001540696,0.0007317917,0.0005909149,0.00001699182,0.0003520703,0.00001263297,0.00009490026,0.0001697246,0.4691136,0.000886524,0.00642608,0.5200641],"study_design_scores_gemma":[0.002101057,0.001064691,0.002383331,0.00004575107,0.00001500364,0.00003225152,0.00006386032,0.0002297254,0.5757854,0.0002687812,0.4174803,0.0005299022],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2592227,0.7270936,0.005620013,0.001768568,0.002635903,0.001733085,0.000602725,0.0002416984,0.001081645],"genre_scores_gemma":[0.9818469,0.01273401,0.0001273021,0.002858878,0.0004296913,0.0001189172,0.0008839963,0.00006150887,0.0009388096],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7226241,"threshold_uncertainty_score":0.9999542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0197475529811363,"score_gpt":0.2656236591770438,"score_spread":0.2458761061959075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}