{"id":"W2102450098","doi":"10.1128/jb.00698-08","title":"Alanylclavam Biosynthetic Genes Are Clustered Together with One Group of Clavulanic Acid Biosynthetic Genes in<i>Streptomyces clavuligerus</i>","year":2008,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Streptomyces clavuligerus; Biology; Transposon mutagenesis; Transposable element; Gene; Gene cluster; Mutant; Genetics; Mutagenesis; Dehydratase; Biochemistry; Propionibacterium freudenreichii; Streptomyces; Actinomycetales; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006573708,0.0005974435,0.0002727734,0.0005126999,0.000224991,0.0003601992,0.0001649665,0.000195599,0.0008006564],"category_scores_gemma":[0.0001884787,0.0002017996,0.0003571546,0.0004176881,0.0001730821,0.0001148842,0.0002541452,0.0003199238,0.0005247031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004530587,"about_ca_system_score_gemma":0.0003535259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001936542,"about_ca_topic_score_gemma":0.001640891,"domain_scores_codex":[0.9998416,0.00001664757,0.00001624949,0.00004687954,0.00004343794,0.00003531285],"domain_scores_gemma":[0.9997626,0.00002394871,0.00009170469,0.00002237905,0.00002738724,0.00007203938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009154979,0.00002017208,0.001915195,0.00002063987,0.000004593657,0.0001241274,0.00002148421,0.0000663217,0.995963,0.00005416051,0.00001900468,0.001699686],"study_design_scores_gemma":[0.00002349104,0.0003580203,0.1045852,0.00002214287,0.00005430507,0.001933806,0.0001550064,0.001794647,0.8867974,0.0001409039,0.00411645,0.00001864072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995374,0.0002731462,0.002755908,0.00003786388,0.00000947512,0.00002048338,0.0005112902,0.0001378809,0.0008798614],"genre_scores_gemma":[0.9880036,0.0001660175,0.005844559,0.00002916686,0.000006609994,0.00001795993,0.003577842,0.00003349525,0.00232076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001936542,"threshold_uncertainty_score":0.003850579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02004391034553751,"score_gpt":0.2340281643906006,"score_spread":0.213984254045063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}