{"id":"W2102467322","doi":"10.1530/jme-10-0117","title":"Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets","year":2011,"lang":"en","type":"article","venue":"Journal of Molecular Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto; University of Prince Edward Island","funders":"Canadian Institutes of Health Research; Canadian Diabetes Association","keywords":"Transactivation; Pancreatic islets; Apoptosis; IκB kinase; NF-κB; Cell biology; Biology; Signal transduction; Endocrinology; Proinflammatory cytokine; Chemistry; Internal medicine; Islet; Gene expression; Inflammation; Insulin; Immunology; Gene; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205274,0.0004240205,0.0003193954,0.0001977437,0.0001055993,0.0003299215,0.0001366189,0.0002858219,0.00122354],"category_scores_gemma":[0.0001266199,0.0001601471,0.0002962538,0.0001805868,0.000232001,0.0002029717,0.0002779488,0.0006930362,0.0002183719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002075017,"about_ca_system_score_gemma":0.0001116253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002142492,"about_ca_topic_score_gemma":0.0003471783,"domain_scores_codex":[0.9998099,0.00003103028,0.00002343739,0.00005414642,0.0000494353,0.00003202283],"domain_scores_gemma":[0.9998237,0.0000186102,0.0000620685,0.00002330541,0.00001284259,0.0000593414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001816938,0.00001687394,0.0002347134,0.00002162404,0.000004593941,0.00005495944,0.000005927751,0.00001256138,0.9991137,0.00001224055,0.00001752963,0.0003233906],"study_design_scores_gemma":[0.00004259511,0.0004800116,0.01989106,0.00001016031,0.00003024547,0.0008724526,0.00005996599,0.0004560815,0.9764478,0.0000556716,0.001647794,0.000006189404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954097,0.00197747,0.001292785,0.0000953783,0.0000564058,0.00001504438,0.0003752595,0.00008253981,0.0006954591],"genre_scores_gemma":[0.995393,0.00108846,0.001287818,0.00008240087,0.0000217916,0.00003897293,0.0005806463,0.00002500352,0.001481831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122354,"threshold_uncertainty_score":0.004093111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091036798768093,"score_gpt":0.2382047223618372,"score_spread":0.2172943543741563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}