{"id":"W2102487178","doi":"10.1164/rccm.201002-0151oc","title":"Loci Identified by Genome-wide Association Studies Influence Different Disease-related Phenotypes in Chronic Obstructive Pulmonary Disease","year":2010,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; GlaxoSmithKline","keywords":"COPD; Medicine; Locus (genetics); Internal medicine; Cohort; Single-nucleotide polymorphism; Genome-wide association study; Pulmonary function testing; Oncology; Genetics; Genotype; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00126979,0.0005683453,0.0003624888,0.001148862,0.0003691257,0.000789875,0.0006304414,0.0009314278,0.002187599],"category_scores_gemma":[0.004051224,0.000199953,0.0007213586,0.001459803,0.0006820185,0.0002432762,0.000708501,0.0006100176,0.00023371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744004,"about_ca_system_score_gemma":0.0003418385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002338622,"about_ca_topic_score_gemma":0.002141424,"domain_scores_codex":[0.9991812,0.0002261934,0.00008684629,0.0003035938,0.0001271368,0.00007509535],"domain_scores_gemma":[0.9969169,0.001393655,0.001120182,0.000230328,0.000134116,0.0002047629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006150545,0.00005213362,0.9833513,0.00007936036,0.0006363458,0.0002966092,0.00006791114,0.0003026844,0.008809072,0.000110434,0.0001107013,0.005568549],"study_design_scores_gemma":[0.000030743,0.00008041131,0.99774,0.00002252877,0.0002853587,0.0003865784,0.00004303257,0.0003356464,0.0006387386,0.0001898098,0.0002406417,0.000006436946],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952444,0.002011265,0.00129385,0.000191005,0.00001855244,0.00002250596,0.0006101234,0.00003144694,0.000576825],"genre_scores_gemma":[0.9982368,0.0002652803,0.0008677657,0.00008043116,0.00002150963,0.00001337516,0.0004129737,0.000007242437,0.00009458092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002338622,"threshold_uncertainty_score":0.007318258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007058325555409785,"score_gpt":0.2904212177569881,"score_spread":0.2833628922015783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}