{"id":"W2102510233","doi":"10.1038/nsmb.2318","title":"Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis","year":2012,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Acetylation; Biochemistry; Acetyltransferase; Lysine; Mycobacterium tuberculosis; Protein structure; Histone acetyltransferase; Fusion protein; Biology; cAMP receptor protein; Protein domain; Cell biology; Transferase; Plasma protein binding; Chemistry; Enzyme; Gene; Gene expression; Amino acid; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500791,0.0001723833,0.0001838075,0.0002159978,0.000273531,0.000347473,0.0002207581,0.0002876472,0.0009110985],"category_scores_gemma":[0.0002577433,0.0001399424,0.0001637279,0.0001770408,0.0002531071,0.0001644895,0.000238283,0.0003110541,0.0003406115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005363025,"about_ca_system_score_gemma":0.0001996631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001846281,"about_ca_topic_score_gemma":0.002069025,"domain_scores_codex":[0.9998546,0.0000204774,0.00001077125,0.00002530584,0.00003610312,0.00005277985],"domain_scores_gemma":[0.9998227,0.00004305345,0.00004297998,0.00002055105,0.00003204322,0.00003865076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004015045,0.00002245141,0.0007212062,0.00002575938,0.000003305995,0.00008349153,0.00002181366,0.0001013148,0.9972029,0.0001390287,0.00003988166,0.001237241],"study_design_scores_gemma":[0.00004703526,0.0003347994,0.05591853,0.00001923612,0.0000170954,0.0004166638,0.0001223131,0.002546087,0.9384693,0.0004458629,0.001646136,0.00001704947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952639,0.002606229,0.0005946463,0.0002070063,0.00004728568,0.000006874127,0.000202878,0.00003189204,0.001039219],"genre_scores_gemma":[0.9988421,0.0003286559,0.0002161228,0.00003196222,0.000007778963,0.000003316973,0.0001372046,0.000003956449,0.0004289593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846281,"threshold_uncertainty_score":0.00389123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005560712741314884,"score_gpt":0.3028254079220177,"score_spread":0.2972646951807029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}