{"id":"W2102510233","doi":"10.1038/nsmb.2318","title":"Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis","year":2012,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Allosteric regulation; Acetylation; Biochemistry; Acetyltransferase; Lysine; Mycobacterium tuberculosis; Protein structure; Histone acetyltransferase; Fusion protein; Biology; cAMP receptor protein; Protein domain; Cell biology; Transferase; Plasma protein binding; Chemistry; Enzyme; Gene; Gene expression; Amino acid; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002211919,0.0002425831,0.0002653119,0.0001373188,0.00003729641,0.000009147073,0.0002311223,0.0009437207,0.00004605708],"category_scores_gemma":[0.0002981198,0.0002088418,0.0001548398,0.0003173432,0.0001650554,0.00001080327,0.000189515,0.0004260782,0.000005269467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003372045,"about_ca_system_score_gemma":0.00003790436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004361736,"about_ca_topic_score_gemma":0.00002489526,"domain_scores_codex":[0.9983405,0.0002206522,0.0003417543,0.0004106112,0.0001804325,0.0005060856],"domain_scores_gemma":[0.999131,0.000007425205,0.0001320922,0.0004264765,0.0001830028,0.000120046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000151799,0.00002948897,0.005322028,0.0000379122,0.0000491998,6.967516e-7,0.00001804214,0.000007912959,0.9900531,0.002009869,0.00006323838,0.002256759],"study_design_scores_gemma":[0.0005099158,0.0001159915,0.04748596,0.00001712331,0.00001489129,0.00001907811,0.000006048801,0.00001170498,0.9472197,0.0008006154,0.00357483,0.0002241683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942455,0.003461167,0.000871157,0.000539054,0.0001637801,0.0004224089,0.0000235966,0.00001210782,0.0002612593],"genre_scores_gemma":[0.9962604,0.00003306559,0.001977147,0.0002782232,0.0002233097,0.00003274405,0.001082659,0.00002782812,0.00008464322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04283338,"threshold_uncertainty_score":0.851632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005560712741314884,"score_gpt":0.3028254079220177,"score_spread":0.2972646951807029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}