{"id":"W2102540663","doi":"10.1128/mcb.00570-12","title":"Splice-Mediated Motif Switching Regulates Disabled-1 Phosphorylation and SH2 Domain Interactions","year":2012,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Montreal Clinical Research Institute; Université de Montréal; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"DAB1; Biology; Phosphorylation; Alternative splicing; Gene isoform; Cell biology; Signal transduction; SH2 domain; Tyrosine; Tyrosine phosphorylation; Effector; Reelin; RNA splicing; Signal transducing adaptor protein; Proto-oncogene tyrosine-protein kinase Src; Genetics; Gene; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685595,0.0002471087,0.0001431095,0.0001206877,0.0001450314,0.0003372604,0.0001967707,0.0001662828,0.001055782],"category_scores_gemma":[0.000143812,0.0001501084,0.0001867341,0.0000866604,0.0002160046,0.0002156973,0.0002511308,0.0002894916,0.0004026126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256755,"about_ca_system_score_gemma":0.0001198017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002702861,"about_ca_topic_score_gemma":0.0006077407,"domain_scores_codex":[0.9998713,0.00002383756,0.00001057739,0.00003129583,0.00003097022,0.00003197609],"domain_scores_gemma":[0.9999,0.00002114553,0.0000382476,0.000009164415,0.000009838134,0.00002150023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004371511,0.000005145005,0.0004552149,0.000007355091,0.000002070806,0.00006265867,0.000009891403,0.00003792182,0.9985251,0.0001845964,0.00001253374,0.000653886],"study_design_scores_gemma":[0.00001568969,0.00005861922,0.01278166,0.000003338292,0.00001172608,0.0004921899,0.00004193176,0.001719068,0.9832746,0.0002007755,0.001394751,0.000005615696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966416,0.0004487738,0.002130009,0.00002365972,0.00001058092,0.000005290698,0.00006339341,0.00001871996,0.0006578298],"genre_scores_gemma":[0.9979396,0.0003014905,0.0009107506,0.00001378652,0.000004675266,0.000006783787,0.0001419301,0.00001099103,0.0006699056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055782,"threshold_uncertainty_score":0.003531933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006899010357696558,"score_gpt":0.2504112053289352,"score_spread":0.2435121949712387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}