{"id":"W2102541302","doi":"10.1158/0008-5472.can-04-0401","title":"Increased Plasma Vascular Endothelial Growth Factor (VEGF) as a Surrogate Marker for Optimal Therapeutic Dosing of VEGF Receptor-2 Monoclonal Antibodies","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Angiogenesis; Monoclonal antibody; Vascular endothelial growth factor; Medicine; Pharmacodynamics; Antibody; Pharmacology; Kinase insert domain receptor; Monoclonal; Pharmacokinetics; Cancer research; Immunology; Vascular endothelial growth factor A; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00118994,0.0004500602,0.0004889001,0.0003187614,0.0001342701,0.0005190072,0.0002606137,0.0005533796,0.0006474926],"category_scores_gemma":[0.001022373,0.0001811764,0.0001848112,0.0002483781,0.000297441,0.0003612066,0.0001750887,0.001300823,0.0002151996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000423708,"about_ca_system_score_gemma":0.0002778627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001635458,"about_ca_topic_score_gemma":0.0002101544,"domain_scores_codex":[0.9988746,0.000528765,0.00009839155,0.0001230184,0.0002875314,0.00008767765],"domain_scores_gemma":[0.9994765,0.0001848564,0.0001772592,0.00005704998,0.00006613005,0.00003822947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003052729,0.0000989836,0.0004994156,0.00007467328,0.000008113314,0.00003077995,0.00001627499,0.0006173197,0.9926892,0.0002248408,0.0001054479,0.005329508],"study_design_scores_gemma":[0.00003495871,0.001734752,0.002309491,0.00001122319,0.00001818451,0.0002396772,0.00001130481,0.00307602,0.9899018,0.0001078462,0.002546264,0.000008520591],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8571828,0.0124299,0.1243239,0.0005582341,0.0002643059,0.0004220818,0.0005325077,0.0005649448,0.003721293],"genre_scores_gemma":[0.9552448,0.001523121,0.04179462,0.0001693978,0.00004558231,0.0002055153,0.0002699609,0.0000461919,0.0007009307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118994,"threshold_uncertainty_score":0.006293118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.050287313681114,"score_gpt":0.3613734736810439,"score_spread":0.3110861599999299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}