{"id":"W2102550103","doi":"10.1242/dmm.013813","title":"An endoplasmic reticulum-retained atrial fibrillation-linked connexin40 mutant impairs atrial gap junction channel function","year":2014,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Gap junction; Endoplasmic reticulum; Mutant; Biology; Connexin; Cell biology; Mutation; Genetics; Gene; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005113566,0.000397588,0.0003453274,0.0001183712,0.0002756713,0.00006542041,0.0002146761,0.0003686527,0.00009362224],"category_scores_gemma":[0.0001553022,0.0003797136,0.0005504743,0.000123685,0.00007652395,0.00002951785,0.00009265414,0.0001311276,0.00003110568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003464282,"about_ca_system_score_gemma":0.0001624912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005316678,"about_ca_topic_score_gemma":0.00004728578,"domain_scores_codex":[0.9974663,0.0003633887,0.0004572482,0.000926808,0.000270951,0.0005153363],"domain_scores_gemma":[0.9983684,0.00003397684,0.0002146378,0.0007365348,0.0002118813,0.0004345495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01516976,0.000128723,0.000142566,0.00006802318,0.0004639707,0.00001570286,0.0001998554,0.1302498,0.7764978,0.06752293,0.000260577,0.009280261],"study_design_scores_gemma":[0.006952732,0.003639964,0.0003233968,0.00002956005,0.000638579,0.00002697392,0.0002407775,0.8684618,0.02414387,0.09061748,0.003762811,0.001162022],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6864949,0.0003016628,0.3107796,0.0001805455,0.001407161,0.0005340561,0.00008234219,0.0001026899,0.000117029],"genre_scores_gemma":[0.9936782,0.0001064256,0.0003103158,0.0003163478,0.003517703,0.00002032486,0.001878045,0.00006535554,0.0001072742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.752354,"threshold_uncertainty_score":0.9998655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525355189482701,"score_gpt":0.2372505887414432,"score_spread":0.2219970368466162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}