{"id":"W2102620699","doi":"10.1200/jco.2007.13.5822","title":"Double-Blind, Randomized Placebo Controlled Trial of Fulvestrant Compared With Exemestane After Prior Nonsteroidal Aromatase Inhibitor Therapy in Postmenopausal Women With Hormone Receptor–Positive, Advanced Breast Cancer: Results From EFECT","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":533,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Exemestane; Medicine; Fulvestrant; Internal medicine; Aromatase inhibitor; Oncology; Placebo; Breast cancer; Adverse effect; Hazard ratio; Clinical endpoint; Cancer; Clinical trial; Aromatase; Tamoxifen; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002418257,0.0003588865,0.003072031,0.0001218578,0.00005017461,0.00001089884,0.0002368874,0.000585548,0.00001448467],"category_scores_gemma":[0.0002627044,0.000206369,0.0003519308,0.000154242,0.0007054741,0.00002698211,0.0000413993,0.0007869276,0.000001784504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007908862,"about_ca_system_score_gemma":0.001642489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006954312,"about_ca_topic_score_gemma":0.0000533725,"domain_scores_codex":[0.9945498,0.001468261,0.002754705,0.0004280225,0.0004043409,0.0003948711],"domain_scores_gemma":[0.9950143,0.001379113,0.002593114,0.0002838948,0.0003842063,0.0003454098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9443905,0.002924304,0.0003866263,0.000004844471,0.001984673,0.0006434857,0.0002497677,0.0002154881,0.04554939,7.339459e-7,0.00008515651,0.003565063],"study_design_scores_gemma":[0.9316584,0.05850494,0.00378542,0.0001318741,0.0002250237,0.0003401758,0.00007426921,0.00002023499,0.004832742,0.000003902462,0.0001757041,0.0002472811],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941174,0.001981356,0.00002712254,0.0004525454,0.0004208544,0.002744127,0.0001657529,0.000005998802,0.00008483625],"genre_scores_gemma":[0.9920984,0.005533777,0.001208333,0.0001532534,0.0006188222,0.0002311013,0.00008592234,0.00003446707,0.00003592045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05558063,"threshold_uncertainty_score":0.8415485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064290175474389,"score_gpt":0.3292825678814817,"score_spread":0.3086396661267379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}