{"id":"W2102674788","doi":"10.18632/oncotarget.4086","title":"MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function","year":2015,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Erasmus Universitair Medisch Centrum Rotterdam; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Children's Health Research Institute; Women and Children's Health Research Institute; Weizmann Institute of Science; Alberta Heritage Foundation for Medical Research; Universität Heidelberg; Loyola University Chicago","keywords":"Mdm2; Ubiquitin ligase; Transactivation; Ubiquitin; Cell biology; Transfection; Biology; Suppressor; Cell cycle checkpoint; Cancer research; Cell culture; Cell cycle; Apoptosis; Chemistry; Molecular biology; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174681,0.0006488499,0.0003188167,0.0003179022,0.0004174459,0.000810458,0.0003042569,0.0004226366,0.001966377],"category_scores_gemma":[0.0001275779,0.0001667515,0.0003420443,0.0002225421,0.0003603902,0.0006207151,0.000402046,0.0006283946,0.0009270996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003989597,"about_ca_system_score_gemma":0.0001675283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001339614,"about_ca_topic_score_gemma":0.0002108935,"domain_scores_codex":[0.9998392,0.00001780998,0.00001335573,0.00004018857,0.00004717836,0.00004220137],"domain_scores_gemma":[0.9999021,0.00001004156,0.00002992517,0.00001354168,0.00001571458,0.00002860012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546229,0.00004285113,0.000981538,0.0001483098,0.00001487466,0.0008426936,0.00003003474,0.0001095578,0.9854047,0.002023312,0.0006104524,0.009637129],"study_design_scores_gemma":[0.00003660451,0.0002255342,0.008455879,0.00002402314,0.00003054111,0.003096417,0.00008634489,0.00182226,0.9676989,0.0007410923,0.01776693,0.00001553192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078333,0.0394648,0.03259768,0.00238991,0.0006667148,0.000122971,0.0008494556,0.0007382212,0.01533693],"genre_scores_gemma":[0.9833832,0.006824658,0.002851129,0.000170214,0.0001937099,0.00004227703,0.0004154539,0.00003222088,0.006087225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966377,"threshold_uncertainty_score":0.006578207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02576868341165241,"score_gpt":0.2825255589317544,"score_spread":0.256756875520102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}