{"id":"W2102674788","doi":"10.18632/oncotarget.4086","title":"MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function","year":2015,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Erasmus Universitair Medisch Centrum Rotterdam; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Children's Health Research Institute; Women and Children's Health Research Institute; Weizmann Institute of Science; Alberta Heritage Foundation for Medical Research; Universität Heidelberg; Loyola University Chicago","keywords":"Mdm2; Ubiquitin ligase; Transactivation; Ubiquitin; Cell biology; Transfection; Biology; Suppressor; Cell cycle checkpoint; Cancer research; Cell culture; Cell cycle; Apoptosis; Chemistry; Molecular biology; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002799331,0.0001753606,0.0003378472,0.0001370936,0.00003316182,0.00001036875,0.00009064813,0.0002019046,0.0001540262],"category_scores_gemma":[0.0005072232,0.0001635714,0.00015717,0.0002092191,0.00002988795,0.0000877339,0.00004481126,0.0001481878,0.00003614582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000154016,"about_ca_system_score_gemma":0.0005146455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006053381,"about_ca_topic_score_gemma":0.000009183913,"domain_scores_codex":[0.9985784,0.00003942144,0.0003348211,0.0003014291,0.0004929152,0.0002530562],"domain_scores_gemma":[0.9986318,0.00003994273,0.0001772446,0.0003388038,0.0004921962,0.0003199668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001099874,0.0002196157,0.0002400329,0.0002104572,0.000150839,0.00003739342,0.0005880235,0.0001101226,0.8917856,0.01730176,0.08593046,0.00232585],"study_design_scores_gemma":[0.007661475,0.002230905,0.0002594953,0.0003281469,0.0004110225,0.00004491924,0.000205017,0.002051715,0.8950354,0.02744847,0.06404801,0.0002753883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5857179,0.004518516,0.3816164,0.008331717,0.003908538,0.003048785,0.0001160355,0.0003864378,0.01235567],"genre_scores_gemma":[0.9800292,0.00005071692,0.01601836,0.0010847,0.0005571935,0.00009285426,0.0004366888,0.00007936156,0.001650924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3943113,"threshold_uncertainty_score":0.6670246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02576868341165241,"score_gpt":0.2825255589317544,"score_spread":0.256756875520102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}