{"id":"W2102703934","doi":"10.1371/journal.pone.0094194","title":"Polybasic Trafficking Signal Mediates Golgi Export, ER Retention or ER Export and Retrieval Based on Membrane-Proximity","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Dalhousie University; Nova Scotia Health Research Foundation","keywords":"Golgi apparatus; Cell biology; Endosome; Cytoplasm; Transmembrane protein; Transmembrane domain; Protein Sorting Signals; Membrane protein; Transport protein; Protein targeting; Biology; Cell membrane; ER retention; Chemistry; Signal peptide; Biochemistry; Endoplasmic reticulum; Peptide sequence; Cell; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557034,0.0007049217,0.0002127372,0.0001867843,0.0002071034,0.0003893146,0.0002565124,0.0002884829,0.002909098],"category_scores_gemma":[0.0001304343,0.0001458546,0.0003211743,0.000156648,0.0002512052,0.0003687522,0.0005134325,0.0004581626,0.001906844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000300629,"about_ca_system_score_gemma":0.0003181448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001853105,"about_ca_topic_score_gemma":0.0002198613,"domain_scores_codex":[0.9998504,0.0000269462,0.00001402604,0.00003763948,0.000034845,0.00003609811],"domain_scores_gemma":[0.9998665,0.00001507052,0.00003872374,0.00001672414,0.00001833511,0.00004459031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001130258,0.00001528673,0.0001610952,0.00005968255,0.000004565934,0.000149487,0.00001385568,0.00003209883,0.9958735,0.0005538948,0.00006905947,0.002954588],"study_design_scores_gemma":[0.00003626214,0.0003644484,0.004168709,0.00001739334,0.00001878356,0.001377346,0.00004778512,0.0006101612,0.9784994,0.0002789806,0.01457239,0.000008260336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846087,0.002521691,0.007726545,0.0001378044,0.00006886358,0.00005179648,0.0005166025,0.0001285976,0.004239491],"genre_scores_gemma":[0.9814667,0.001642745,0.004887104,0.00006978056,0.00002923757,0.00004929347,0.001809966,0.00003642769,0.01000861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002909098,"threshold_uncertainty_score":0.009731889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02673252510429446,"score_gpt":0.210096366481379,"score_spread":0.1833638413770845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}