{"id":"W2102726155","doi":"10.4049/jimmunol.1000105","title":"Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against <i>Bordetella pertussis</i>","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Bordetella pertussis; Pertussis toxin; Adenylate kinase; Cyclase; Inflammasome; Microbiology; Toxin; Adenylate Cyclase Toxin; Chemistry; Biology; G protein; Bacteria; Biochemistry; Enzyme; Signal transduction; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448756,0.0005257129,0.0003646676,0.0002869066,0.0002243306,0.0004584468,0.0001914634,0.0005901665,0.00123654],"category_scores_gemma":[0.0001476391,0.0002106883,0.0006197385,0.000141809,0.0005696211,0.0004186777,0.0002953179,0.00142501,0.0003743537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004844922,"about_ca_system_score_gemma":0.0003689626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005685407,"about_ca_topic_score_gemma":0.0008715239,"domain_scores_codex":[0.9997334,0.00004338361,0.00003068383,0.00005427804,0.00006017074,0.00007815121],"domain_scores_gemma":[0.9998174,0.00002582522,0.00007613633,0.00002367533,0.00001353047,0.00004338316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001728613,0.00001996303,0.0001206325,0.00004222818,0.000003588259,0.00004851973,0.00001481471,0.00003552163,0.999049,0.00007846374,0.00002383525,0.0003907303],"study_design_scores_gemma":[0.00006817604,0.0006565787,0.004627532,0.00001467577,0.00002254787,0.0005308237,0.0000419628,0.0004876302,0.9917194,0.0001133748,0.001711751,0.000005502459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904687,0.00252924,0.003916167,0.0004801351,0.00008753758,0.0000640449,0.0005799668,0.0001301822,0.001744199],"genre_scores_gemma":[0.993562,0.001370899,0.002891608,0.0001390665,0.00003895403,0.0000601014,0.0003995911,0.0000273605,0.001510458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123654,"threshold_uncertainty_score":0.004136622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008312426393666984,"score_gpt":0.2218894800531429,"score_spread":0.2135770536594759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}