{"id":"W2102726155","doi":"10.4049/jimmunol.1000105","title":"Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against <i>Bordetella pertussis</i>","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"","keywords":"Bordetella pertussis; Pertussis toxin; Adenylate kinase; Cyclase; Inflammasome; Microbiology; Toxin; Adenylate Cyclase Toxin; Chemistry; Biology; G protein; Bacteria; Biochemistry; Enzyme; Signal transduction; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006523394,0.0001592798,0.0002614839,0.0001646452,0.0003539056,0.00002728445,0.0001832192,0.0003170419,0.0001344],"category_scores_gemma":[0.0004084027,0.0001007127,0.00006381817,0.0001257398,0.0002429647,0.0002288467,0.00006771434,0.0009094206,0.0000274237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002212184,"about_ca_system_score_gemma":0.00005952591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008096824,"about_ca_topic_score_gemma":0.00004320312,"domain_scores_codex":[0.9987324,0.0005191042,0.0003965765,0.0001095079,0.00002061191,0.0002218278],"domain_scores_gemma":[0.9988483,0.0003148847,0.0004421166,0.0002120266,0.0001639144,0.00001872879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001491395,0.00005739662,0.0002171123,0.000003891344,0.0001797337,8.425417e-7,0.000250532,0.00000134787,0.9784052,0.00004673304,0.0007533297,0.01859252],"study_design_scores_gemma":[0.001327049,0.0005803658,0.01532353,0.00002866267,0.00005530028,0.001055906,0.0001465165,0.00000214471,0.8853073,0.0001186556,0.09592312,0.0001314257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938369,0.001526792,0.0000640499,0.002605315,0.001620612,0.0001736725,0.000006813266,0.00002751331,0.0001383761],"genre_scores_gemma":[0.997561,0.001290855,0.00002068775,0.0001039051,0.0001236586,0.000006831585,0.00000470751,0.00001521794,0.0008731047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09516979,"threshold_uncertainty_score":0.4106945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008312426393666984,"score_gpt":0.2218894800531429,"score_spread":0.2135770536594759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}