{"id":"W2102727846","doi":"10.1634/theoncologist.2011-0450","title":"The Utility of Hedgehog Signaling Pathway Inhibition for Cancer","year":2012,"lang":"en","type":"review","venue":"The Oncologist","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Hedgehog signaling pathway; Hedgehog; Signal transduction; Cancer research; Smoothened; Metastasis; Biology; Downregulation and upregulation; Cancer; Bioinformatics; Medicine; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001698848,0.0003322781,0.0007861477,0.00002106596,0.0004401437,0.00002164911,0.0004539409,0.0003679445,0.0000128194],"category_scores_gemma":[0.0003786295,0.0001672748,0.0005535196,0.0001125795,0.0006311067,0.000001883841,0.0002590184,0.0002166993,0.00000621838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005566904,"about_ca_system_score_gemma":0.000454038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003502553,"about_ca_topic_score_gemma":0.0001561662,"domain_scores_codex":[0.9981493,0.0003714196,0.000600251,0.0003354364,0.0001407364,0.0004028869],"domain_scores_gemma":[0.9980306,0.0004938254,0.0006338723,0.000609305,0.0001852301,0.0000471444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000475683,0.00006860123,0.000007531741,0.003193321,0.0003658146,5.770002e-7,0.00006720268,0.000002444047,0.001771187,0.000123829,0.002872192,0.9914798],"study_design_scores_gemma":[0.0001264921,0.0001462956,0.000003542469,0.0006776257,0.0004879588,0.000004513106,0.00006414607,0.000002357998,0.005453493,0.00006538699,0.9927706,0.000197656],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002547503,0.996483,0.0003337137,0.00008854399,0.0005669334,0.001236726,0.0003482932,0.00001414788,0.0006739405],"genre_scores_gemma":[0.009897726,0.9871577,0.00007915823,0.00005218466,0.001098773,0.0009514467,0.0001650022,0.00004570982,0.0005523232],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.991282,"threshold_uncertainty_score":0.6821269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1417067204821225,"score_gpt":0.3886677874465042,"score_spread":0.2469610669643817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}