{"id":"W2102728030","doi":"10.1186/1476-4598-13-72","title":"Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma","year":2014,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Hyundai Hope On Wheels; Morgan Adams Foundation; Childhood Brain Tumor Foundation","keywords":"Medulloblastoma; Kinome; Wee1; Biology; RNA interference; Cancer research; Mitosis; Kinase; Cell cycle; Cell growth; Gene knockdown; Mitotic catastrophe; Cell cycle checkpoint; Cell biology; Cell; Cell culture; Genetics; Gene; Cyclin-dependent kinase 1; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238543,0.0004265966,0.0002996343,0.0005246119,0.0001244466,0.0003094713,0.0002870344,0.0002470792,0.001366846],"category_scores_gemma":[0.0001434373,0.0001591512,0.0003334682,0.000281298,0.0001903834,0.0001739988,0.0001943697,0.0004422897,0.0002486046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005605072,"about_ca_system_score_gemma":0.0003826992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008041369,"about_ca_topic_score_gemma":0.001608576,"domain_scores_codex":[0.9999186,0.000005827321,0.000004112572,0.00002077919,0.00003577137,0.00001489566],"domain_scores_gemma":[0.9999495,0.000009308165,0.00001968243,0.000004305018,0.000008245822,0.000008976211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001406889,0.00002863427,0.001108524,0.00006567584,0.00001822379,0.00007767726,0.000006625735,0.0003436452,0.992835,0.0001058996,0.00007474155,0.005194615],"study_design_scores_gemma":[0.00006026522,0.0008263564,0.03573173,0.00001290494,0.0002201809,0.001079177,0.00003803687,0.004383348,0.9517471,0.0002662322,0.005624104,0.00001056512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804195,0.004820559,0.01007111,0.0002799189,0.00003232037,0.0001163096,0.002063252,0.0003656765,0.001831404],"genre_scores_gemma":[0.982676,0.002431876,0.01040875,0.00009147883,0.00001239941,0.00004728259,0.003129435,0.0000386416,0.001164041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366846,"threshold_uncertainty_score":0.00457257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129454595192634,"score_gpt":0.2661876975389391,"score_spread":0.2548931515870127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}