{"id":"W2102736458","doi":"10.1074/jbc.m112.339580","title":"Hormone-induced 14-3-3γ Adaptor Protein Regulates Steroidogenic Acute Regulatory Protein Activity and Steroid Biosynthesis in MA-10 Leydig Cells","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Steroidogenic acute regulatory protein; Cholesterol side-chain cleavage enzyme; Biology; Immunoprecipitation; Cell biology; Leydig cell; Cytosol; Sterol; Steroid hormone; Steroid; Steroid biosynthesis; Mitochondrion; Inner mitochondrial membrane; Hormone; Chemistry; Biochemistry; Gene expression; Messenger RNA; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006078684,0.0001571666,0.0001793887,0.0002100356,0.0001911796,0.0003074856,0.0001769556,0.0001579717,0.001601652],"category_scores_gemma":[0.00005295243,0.0001353156,0.0003420674,0.000181667,0.0001683687,0.0001332463,0.0002040328,0.0005232305,0.0006527151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995981,"about_ca_system_score_gemma":0.0002428771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001698373,"about_ca_topic_score_gemma":0.001821224,"domain_scores_codex":[0.999912,0.000008865197,0.000007508484,0.00001977637,0.00002573468,0.00002608592],"domain_scores_gemma":[0.9999447,0.000004567493,0.00001111211,0.000005291532,0.000008638029,0.00002580409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008969871,0.00002142396,0.0004034543,0.00002409373,0.000004406561,0.00005908302,0.00001847609,0.00002349665,0.9986463,0.00008476467,0.00007308007,0.0005517947],"study_design_scores_gemma":[0.00005683003,0.000188837,0.0689235,0.00001400353,0.00003686581,0.0003884732,0.0001911533,0.00192308,0.9179759,0.0001289359,0.01015889,0.00001360577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924543,0.002688723,0.001489982,0.0002231687,0.00007747949,0.00001938845,0.0009451842,0.0001322491,0.001969486],"genre_scores_gemma":[0.9904121,0.000987223,0.0006795861,0.0001154389,0.00001188913,0.00002783017,0.001340575,0.00002051894,0.006404885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698373,"threshold_uncertainty_score":0.0053581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965784862211171,"score_gpt":0.2491227602028046,"score_spread":0.2294649115806929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}