{"id":"W2102773999","doi":"10.1186/1476-4598-9-125","title":"Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; National Institutes of Health; Gary Bennett Family Fund; National Cancer Institute; Entertainment Industry Foundation","keywords":"Microsatellite instability; DNA methylation; Colorectal cancer; Biology; Methylation; KRAS; Carcinogenesis; CpG site; Oncology; Cancer; Epigenomics; Cancer research; Internal medicine; Genetics; Microsatellite; Medicine; Gene expression; Gene; Allele","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002054039,0.0001172068,0.0001784491,0.00008169534,0.00003279914,0.000003547055,0.0001703947,0.0001456065,0.00006008494],"category_scores_gemma":[0.00005880242,0.0001253316,0.00006476389,0.0001766191,0.0000935979,0.000004910905,0.0001826472,0.0001265767,6.01062e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002419324,"about_ca_system_score_gemma":0.0001467914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002641873,"about_ca_topic_score_gemma":0.001738577,"domain_scores_codex":[0.9991136,0.00005632795,0.0002583068,0.0002634162,0.0001532644,0.0001550717],"domain_scores_gemma":[0.9994102,0.000008881002,0.0002105896,0.0002097533,0.0001062031,0.00005436086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000830545,0.00006113306,0.06608993,0.0000265187,0.00003610708,0.000001268317,0.00008341009,0.0007404896,0.9314345,0.00001441457,0.00003962483,0.001389554],"study_design_scores_gemma":[0.0005231539,0.00008595502,0.02543196,0.00001771691,0.00002320958,1.719254e-7,0.00001189919,0.0002559392,0.9730288,0.00004570148,0.0004493445,0.0001260853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937437,0.003951842,0.001528911,0.00004739677,0.0001349355,0.0002066166,0.0002993135,0.000003442275,0.00008382452],"genre_scores_gemma":[0.9985632,0.0006432669,0.0004164611,0.00002994047,0.0000266439,0.00002816185,0.0002494964,0.00001624022,0.00002654959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04159437,"threshold_uncertainty_score":0.5110875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009283935489756211,"score_gpt":0.2700280811493474,"score_spread":0.2607441456595912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}