{"id":"W2102780227","doi":"10.1523/jneurosci.0306-10.2010","title":"A Role for Protein Kinase C-Dependent Upregulation of Adrenomedullin in the Development of Morphine Tolerance in Male Rats","year":2010,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Adrenomedullin; Calcitonin gene-related peptide; Downregulation and upregulation; Dorsal root ganglion; Chemistry; Internal medicine; Hyperalgesia; Agonist; Protein kinase C; Endocrinology; Receptor; Pharmacology; Opioid; Opioid receptor; Nociception; Spinal cord; Neuropeptide; Signal transduction; Medicine; Biology; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019411,0.0005650632,0.0004241788,0.0003524284,0.0002153628,0.0002777393,0.0002096777,0.0003366922,0.001911797],"category_scores_gemma":[0.0001150549,0.0002094026,0.0004420608,0.0001381504,0.0003749911,0.0002804269,0.0002443306,0.0009406077,0.0003346427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004232163,"about_ca_system_score_gemma":0.0003608204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005098325,"about_ca_topic_score_gemma":0.0008995236,"domain_scores_codex":[0.9998696,0.00001287174,0.000008444926,0.00003309159,0.00002802988,0.00004800126],"domain_scores_gemma":[0.9998413,0.000005847401,0.0000595597,0.00001400697,0.00001341336,0.00006572801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000839596,0.0001108642,0.0005128152,0.00005726814,0.000009617028,0.0001756076,0.00001564216,0.00002992624,0.9952164,0.0001368159,0.00004360417,0.002851915],"study_design_scores_gemma":[0.0001616503,0.004217208,0.09407446,0.00003870505,0.0001020908,0.001141015,0.0001427942,0.0009554188,0.8950785,0.0003149214,0.003731139,0.00004206742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913903,0.005053342,0.001422446,0.0002435906,0.00009188529,0.00004038092,0.0002639074,0.00007398451,0.001420193],"genre_scores_gemma":[0.9908241,0.003069311,0.001590148,0.0001558116,0.00004020239,0.0001371554,0.0002815873,0.00001786601,0.003883851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001911797,"threshold_uncertainty_score":0.006395578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03311397662057151,"score_gpt":0.2758551192541682,"score_spread":0.2427411426335967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}