{"id":"W2102843554","doi":"10.1212/wnl.0b013e3182a8237e","title":"Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers","year":2013,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Alzheimer Society of Manitoba; Fidelity Biosciences; Canadian Institutes of Health Research; Ministry of Health, British Columbia; Kyowa Hakko Kirin; Association for Frontotemporal Degeneration; National Institutes of Health; Canada Research Chairs; Alzheimer Society; Fondation pour la Recherche sur Alzheimer; Parkinson Study Group; CurePSP; F. Hoffmann-La Roche; Massachusetts General Hospital; Teva Pharmaceutical Industries; Yale University; Pfizer; Biogen; ALS Therapy Alliance; Alzheimer Society of B.C.; Genentech; Eli Lilly and Company; Bristol-Myers Squibb; Michael J. Fox Foundation for Parkinson's Research","keywords":"Frontotemporal dementia; Psychology; Fluorodeoxyglucose; Statistical parametric mapping; Frontotemporal lobar degeneration; Dementia; Internal medicine; Medicine; Cardiology; Pathology; Neuroscience; Positron emission tomography; Radiology; Magnetic resonance imaging; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706637,0.0001259644,0.000268579,0.0002145915,0.00003432386,0.00002595452,0.0001169951,0.0001385355,0.0008598548],"category_scores_gemma":[0.0002042213,0.00010501,0.00004966539,0.0002722291,0.0001379358,0.0001395841,0.00007237483,0.0003372942,0.0002532898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001709099,"about_ca_system_score_gemma":0.00005013882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008591852,"about_ca_topic_score_gemma":0.00009620109,"domain_scores_codex":[0.9985278,0.0001922654,0.0002859215,0.0003264721,0.0002086602,0.0004588927],"domain_scores_gemma":[0.9994211,0.00007325761,0.00005141049,0.0002240032,0.00007621901,0.0001540229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001226559,0.0003747117,0.340586,0.0001021881,0.0001167385,0.0005080621,0.0007991671,0.00003055376,0.5476202,0.00007371241,0.00219814,0.1063639],"study_design_scores_gemma":[0.002095277,0.001071451,0.9906061,0.00001112842,0.00001927329,0.00008461523,0.000007025738,0.001440853,0.001520149,0.0002442882,0.002817891,0.00008199819],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815364,0.0005014159,0.0000164303,0.01661484,0.0001256535,0.0009315824,0.000002900598,0.00005705883,0.0002137092],"genre_scores_gemma":[0.9958745,0.00009519113,0.0002698542,0.003324306,0.00008882058,0.000209312,0.00002146895,0.00002445476,0.00009207052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.65002,"threshold_uncertainty_score":0.9414807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317858982984813,"score_gpt":0.2756080683052283,"score_spread":0.2624294784753802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}