{"id":"W2102862906","doi":"10.2337/diabetes.54.6.1676","title":"Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes","year":2005,"lang":"en","type":"article","venue":"Diabetes","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Naringenin; Microsomal triglyceride transfer protein; Protein kinase A; MAPK/ERK pathway; Internal medicine; Chemistry; Insulin; Insulin receptor; Endocrinology; Kinase; Biology; Biochemistry; Insulin resistance; Lipoprotein; Cholesterol; Very low-density lipoprotein; Flavonoid; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002105174,0.0002382883,0.0002350313,0.00006331625,0.0001040651,0.00002476414,0.0001279952,0.000266353,0.000006982745],"category_scores_gemma":[0.00009692692,0.000167078,0.00005819423,0.0001866359,0.0002565118,0.00004010585,0.0000894761,0.0001980048,1.899727e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003315588,"about_ca_system_score_gemma":0.00005437361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001523304,"about_ca_topic_score_gemma":0.00001930266,"domain_scores_codex":[0.9985893,0.0002440848,0.0003901168,0.0003594041,0.0001745523,0.0002425033],"domain_scores_gemma":[0.999446,0.00001953737,0.0001741625,0.0002377539,0.00006899598,0.00005351467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003394552,0.000115816,0.002536653,0.00008826032,0.00002585674,5.251492e-8,0.0004097411,0.000005935475,0.9922999,0.000004492715,0.00002796073,0.004145874],"study_design_scores_gemma":[0.001489669,0.0002064792,0.0003173248,0.0002443889,0.000005854412,3.923144e-7,0.000125278,0.00008620054,0.9969521,0.00003225284,0.0003491983,0.0001908662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964982,0.001727125,0.00003345777,0.0001690782,0.00001882354,0.00143638,0.00009727142,0.00001186371,0.000007778011],"genre_scores_gemma":[0.999197,0.00005103047,0.00009243657,0.000045251,0.00004777651,0.0003646176,0.0001349805,0.00002965141,0.00003723334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004652193,"threshold_uncertainty_score":0.6813245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005113993908223302,"score_gpt":0.1904929925112539,"score_spread":0.1853789986030306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}