{"id":"W2102862906","doi":"10.2337/diabetes.54.6.1676","title":"Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes","year":2005,"lang":"en","type":"article","venue":"Diabetes","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Naringenin; Microsomal triglyceride transfer protein; Protein kinase A; MAPK/ERK pathway; Internal medicine; Chemistry; Insulin; Insulin receptor; Endocrinology; Kinase; Biology; Biochemistry; Insulin resistance; Lipoprotein; Cholesterol; Very low-density lipoprotein; Flavonoid; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262878,0.0004807929,0.0002477995,0.0001696351,0.0001087679,0.0001377138,0.0001141948,0.0002131203,0.0008151954],"category_scores_gemma":[0.00007728476,0.0001462559,0.0002933751,0.0001092958,0.0002030766,0.0001687226,0.0001214596,0.0004161299,0.0001962672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788752,"about_ca_system_score_gemma":0.0001631657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005756453,"about_ca_topic_score_gemma":0.0007812693,"domain_scores_codex":[0.9999204,0.00001455374,0.00001007795,0.00001774236,0.00001830895,0.00001886896],"domain_scores_gemma":[0.9999577,0.00000839833,0.000009966267,0.000006377778,0.000004470123,0.00001312831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002964572,0.0000354628,0.00007641767,0.00003027938,0.00000385048,0.00002941032,0.000006537356,0.0000332384,0.998385,0.00004032085,0.00002072731,0.001042449],"study_design_scores_gemma":[0.00007757927,0.0006638975,0.005186801,0.000003669248,0.00001250058,0.0001560758,0.00001352073,0.0005298659,0.9920402,0.0000417,0.001268332,0.00000576478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951642,0.001893646,0.001429128,0.00009482798,0.00003118416,0.00003735689,0.0001301639,0.00005976803,0.001159709],"genre_scores_gemma":[0.9946114,0.001061353,0.00180496,0.00005364844,0.00001172452,0.00007655898,0.0002489735,0.00001137856,0.002119936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008151954,"threshold_uncertainty_score":0.002727032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005113993908223302,"score_gpt":0.1904929925112539,"score_spread":0.1853789986030306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}