{"id":"W2102877564","doi":"10.1007/s00125-010-1759-z","title":"Voltage-dependent K+ channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans","year":2010,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Alberta Diabetes Foundation; Fondation pour la Recherche Médicale; University of Alberta; Canadian Diabetes Association","keywords":"Glucagon; Alpha cell; Endocrinology; Internal medicine; Depolarization; Secretion; Membrane potential; Potassium channel; Patch clamp; Chemistry; Biology; Alpha (finance); Biophysics; Cell biology; Beta cell; Electrophysiology; Islet; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003620842,0.001034824,0.0006419573,0.0008814327,0.0003068598,0.0007546037,0.000412057,0.001068928,0.002411059],"category_scores_gemma":[0.000532732,0.0003962064,0.0005295373,0.0002949144,0.001243851,0.0005749374,0.0003422489,0.001298185,0.0003554498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524526,"about_ca_system_score_gemma":0.0001827253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004482594,"about_ca_topic_score_gemma":0.000235808,"domain_scores_codex":[0.9997239,0.00005848936,0.00004103593,0.00008923531,0.00004310979,0.00004423534],"domain_scores_gemma":[0.9996394,0.00007624149,0.0001453747,0.00004393443,0.00001949935,0.00007551273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01646883,0.0005291774,0.01357512,0.0002835076,0.0003073131,0.004169524,0.0001926084,0.0004773109,0.9395568,0.005768659,0.002041844,0.01662931],"study_design_scores_gemma":[0.007115398,0.008182348,0.2988211,0.0006642012,0.003599382,0.06523316,0.00141041,0.008402398,0.5336195,0.01979303,0.05279402,0.0003650259],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983854,0.005224647,0.005875487,0.001216414,0.0002516077,0.00003559529,0.001170076,0.0002634876,0.0021088],"genre_scores_gemma":[0.9920903,0.003106174,0.001768862,0.0005380656,0.0001562825,0.00006249174,0.0006092635,0.00009444786,0.001574078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002411059,"threshold_uncertainty_score":0.00806582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128895681268208,"score_gpt":0.2431159815024236,"score_spread":0.2302264133756028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}