{"id":"W2102910526","doi":"10.1016/j.bmcl.2004.07.070","title":"Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.","year":2004,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"Quinazolinone; Efflux; Chemistry; Fluconazole; Candida albicans; Drug discovery; Pharmacology; Combinatorial chemistry; Antifungal; Biochemistry; Microbiology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849654,0.0004525858,0.0003736774,0.0002690838,0.0001514216,0.0002180788,0.0004736718,0.0003334202,0.001550178],"category_scores_gemma":[0.0002534537,0.0002235709,0.0002436632,0.0001834379,0.000210133,0.0002577148,0.0001838038,0.0004500015,0.0003428624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319145,"about_ca_system_score_gemma":0.0002227536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005524455,"about_ca_topic_score_gemma":0.001358627,"domain_scores_codex":[0.9999245,0.00001462014,0.000007076181,0.00001470198,0.00002067581,0.00001847851],"domain_scores_gemma":[0.9999447,0.000009738244,0.00001342168,0.000006679791,0.00001116641,0.00001419376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006960308,0.0002772986,0.000388527,0.0003810995,0.00004533026,0.0003535791,0.00006080147,0.0009887984,0.9530024,0.0003512427,0.001169975,0.04228486],"study_design_scores_gemma":[0.001259854,0.007885329,0.009711481,0.00006396601,0.000208222,0.002830209,0.00003349558,0.002001066,0.9538093,0.0002140846,0.02191802,0.00006499155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9432247,0.03527076,0.01084924,0.001031345,0.0001875135,0.0006308836,0.001908236,0.0003931354,0.006504138],"genre_scores_gemma":[0.972635,0.01442409,0.006901527,0.0003074103,0.00006943077,0.0001451747,0.001640287,0.00002678301,0.003850242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550178,"threshold_uncertainty_score":0.005185843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346860490520435,"score_gpt":0.2668651093546526,"score_spread":0.2533965044494483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}