{"id":"W2102915129","doi":"10.1016/j.mehy.2008.02.014","title":"Proteasome inhibition as a novel therapy in treating rheumatoid arthritis","year":2008,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Pannus; Medicine; Rheumatoid arthritis; Apoptosis; Cancer research; Proteasome; In vivo; Proteasome inhibitor; Multiple myeloma; Immunology; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006431231,0.000170242,0.0005038771,0.0001929562,0.0001055622,0.0000135442,0.00007238797,0.0001404223,0.001761065],"category_scores_gemma":[0.005837202,0.000118201,0.0001190385,0.0002603364,0.0002213636,0.00009078067,0.00003346539,0.0003254802,0.0002150126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008585503,"about_ca_system_score_gemma":0.000392309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000816777,"about_ca_topic_score_gemma":0.00009052274,"domain_scores_codex":[0.9976166,0.000132386,0.0004237494,0.0002888236,0.001127912,0.0004105573],"domain_scores_gemma":[0.9987274,0.0005118077,0.00006416177,0.0001989996,0.00005590909,0.000441761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0009227926,0.003057018,0.2613585,0.00005489861,0.0001452705,0.006124459,0.0009997851,5.193651e-7,0.006757487,0.0002305279,0.0004181245,0.7199306],"study_design_scores_gemma":[0.06146067,0.004989035,0.8269245,0.006614332,0.00001376598,0.01269194,0.0006660952,0.00143289,0.06325188,0.00137145,0.01978718,0.0007962336],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910786,0.001628085,0.0001106359,0.001725879,0.000027068,0.0008576671,0.000008428786,0.00008175865,0.004481879],"genre_scores_gemma":[0.9892779,0.008346475,0.0009825258,0.000550319,0.00009979352,0.0003151972,0.0000279611,0.00002713697,0.0003726902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7191344,"threshold_uncertainty_score":0.9991515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05521311205147472,"score_gpt":0.3094880683078491,"score_spread":0.2542749562563744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}