{"id":"W2102917986","doi":"10.1177/1087057114520973","title":"Assay Development and High-Throughput Screening for Inhibitors of Kaposi’s Sarcoma–Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes","year":2014,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Human Genome Research Institute; Research England; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Nucleosome; Histone; Kaposi's sarcoma-associated herpesvirus; DNA; Molecular biology; Mitosis; Extrachromosomal DNA; Virology; Plasmid; Cell biology; Genetics; Virus; Herpesviridae","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001558141,0.001570838,0.001551649,0.001431498,0.0005462338,0.0008523782,0.00128878,0.001160642,0.002309609],"category_scores_gemma":[0.001076514,0.0008734838,0.001011378,0.001115,0.0004656585,0.0007020182,0.0007429559,0.001410095,0.001439177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008815537,"about_ca_system_score_gemma":0.0008732133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009890915,"about_ca_topic_score_gemma":0.00319854,"domain_scores_codex":[0.9980494,0.0003608242,0.0001232628,0.0003095496,0.0009837708,0.0001731688],"domain_scores_gemma":[0.9993128,0.0001625696,0.00009488608,0.00006907343,0.0002774008,0.00008317311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002776563,0.0007218003,0.0005911186,0.0007276036,0.0001520718,0.0001071813,0.00008375229,0.002244024,0.9690195,0.000500914,0.00179692,0.0237775],"study_design_scores_gemma":[0.0001465033,0.003222282,0.001786854,0.00005342268,0.0001494798,0.000372415,0.00006182216,0.006983621,0.9703499,0.0001775271,0.01663184,0.00006430168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5726063,0.02581226,0.3558147,0.001424707,0.0005988586,0.007367296,0.009253304,0.004675,0.02244762],"genre_scores_gemma":[0.7074243,0.0218577,0.222568,0.001084178,0.0002126982,0.00752388,0.01395301,0.0004798102,0.02489647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309609,"threshold_uncertainty_score":0.008240342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659255804403844,"score_gpt":0.2587043403493458,"score_spread":0.2421117823053074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}