{"id":"W2102917986","doi":"10.1177/1087057114520973","title":"Assay Development and High-Throughput Screening for Inhibitors of Kaposi’s Sarcoma–Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes","year":2014,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Human Genome Research Institute; Research England; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Nucleosome; Histone; Kaposi's sarcoma-associated herpesvirus; DNA; Molecular biology; Mitosis; Extrachromosomal DNA; Virology; Plasmid; Cell biology; Genetics; Virus; Herpesviridae","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007438207,0.0003507941,0.0007899363,0.0002447962,0.0003157849,0.0001001385,0.0001510167,0.0002796502,0.00002583641],"category_scores_gemma":[0.0005914962,0.0003342827,0.0001910526,0.0004208768,0.0001007658,0.0003534792,0.0001331074,0.0002152189,0.00001346208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003176595,"about_ca_system_score_gemma":0.000184415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003882257,"about_ca_topic_score_gemma":0.0002527052,"domain_scores_codex":[0.997565,0.0001051167,0.0006397293,0.0005339076,0.0004868651,0.0006694354],"domain_scores_gemma":[0.9988331,0.0001771567,0.0003953215,0.0002279153,0.000149731,0.0002167563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004712434,0.003102013,0.7033465,0.001071871,0.005196729,0.0001173709,0.01509017,0.0002853892,0.08858866,0.00641033,0.02827503,0.1438035],"study_design_scores_gemma":[0.04305666,0.00625855,0.8313691,0.005889617,0.001515084,0.00002815734,0.006702858,0.003104754,0.05636182,0.002087301,0.04005588,0.003570249],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966298,0.0001773249,0.0006689748,0.0006326414,0.000288771,0.0006773031,0.0001028897,0.0001148321,0.0007074281],"genre_scores_gemma":[0.9960755,0.00005486142,0.002214777,0.0006046551,0.0000955544,0.00003019215,0.0001518344,0.0000952805,0.0006773369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1402332,"threshold_uncertainty_score":0.9999109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659255804403844,"score_gpt":0.2587043403493458,"score_spread":0.2421117823053074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}