{"id":"W2102953537","doi":"10.1091/mbc.e08-10-1061","title":"Uncoupling Stress Granule Assembly and Translation Initiation Inhibition","year":2009,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; McGill University; Université Laval; Hôpital Saint-François d'Assise; Centre hospitalier universitaire de Québec","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"EIF4G; Stress granule; EIF4E; Eukaryotic initiation factor; Initiation factor; Eukaryotic translation; Biology; eIF2; Internal ribosome entry site; EIF4A1; eIF4A; Cell biology; Translation (biology); Eukaryotic Small Ribosomal Subunit; Protein biosynthesis; Eukaryotic translation initiation factor 4 gamma; EIF4EBP1; Integrated stress response; Messenger RNA; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152966,0.000370405,0.0002920102,0.0001505146,0.00009588465,0.0003067118,0.0001816805,0.0002109004,0.001180131],"category_scores_gemma":[0.0001758736,0.000154924,0.000238493,0.0001098864,0.0002283499,0.0001435494,0.0004092556,0.0004823285,0.0004298808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105803,"about_ca_system_score_gemma":0.0001932725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002416709,"about_ca_topic_score_gemma":0.000412928,"domain_scores_codex":[0.9998224,0.00003173151,0.00001964303,0.0000395542,0.0000524008,0.00003416295],"domain_scores_gemma":[0.999777,0.00005731279,0.00007808868,0.00003641411,0.00001957799,0.00003162759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001007817,0.00001837482,0.00007922898,0.00003440472,0.000004439401,0.0000395282,0.000006221514,0.00007723504,0.9976702,0.0002238142,0.00005775635,0.001688066],"study_design_scores_gemma":[0.00001998677,0.0001306604,0.001526688,0.000005904619,0.000006666931,0.000107974,0.000005687337,0.0009187331,0.9944273,0.00009531363,0.002752299,0.000002744672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982583,0.003783387,0.009501562,0.0001754061,0.0000772967,0.00005422861,0.0002926418,0.0004186023,0.00311384],"genre_scores_gemma":[0.9901334,0.001306049,0.004394959,0.00009094598,0.00002100417,0.00005666131,0.0005523841,0.00006408003,0.00338047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180131,"threshold_uncertainty_score":0.003947973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009786688706743894,"score_gpt":0.2635121786493482,"score_spread":0.2537254899426044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}