{"id":"W2102953537","doi":"10.1091/mbc.e08-10-1061","title":"Uncoupling Stress Granule Assembly and Translation Initiation Inhibition","year":2009,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; McGill University; Université Laval; Hôpital Saint-François d'Assise; Centre hospitalier universitaire de Québec","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"EIF4G; Stress granule; EIF4E; Eukaryotic initiation factor; Initiation factor; Eukaryotic translation; Biology; eIF2; Internal ribosome entry site; EIF4A1; eIF4A; Cell biology; Translation (biology); Eukaryotic Small Ribosomal Subunit; Protein biosynthesis; Eukaryotic translation initiation factor 4 gamma; EIF4EBP1; Integrated stress response; Messenger RNA; Molecular biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490224,0.00007831034,0.00008039877,0.00003179174,0.00006301021,0.000007456905,0.00008365705,0.0001192075,0.000001618191],"category_scores_gemma":[0.00002769253,0.00006164247,0.00005642544,0.00006253356,0.00006408499,0.000003060082,0.00002885711,0.00006990798,6.238661e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004580441,"about_ca_system_score_gemma":0.00002101554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000114231,"about_ca_topic_score_gemma":0.000009363744,"domain_scores_codex":[0.9994237,0.00007833758,0.0001274687,0.0001694805,0.00006339927,0.0001375445],"domain_scores_gemma":[0.9996831,0.000007915997,0.00006570503,0.0001677678,0.00004442407,0.00003101904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002791624,0.00002531787,0.001147349,0.00001043887,0.000005812119,6.48615e-7,0.00001484047,0.0001146497,0.9959337,0.0001028059,0.0000169643,0.002599612],"study_design_scores_gemma":[0.0003676899,0.000220298,0.002510092,0.00001227434,0.000009570976,0.000002740868,0.00001303342,0.0003282285,0.9956598,0.000683735,0.0001248168,0.00006777296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892545,0.001020239,0.008545562,0.000366849,0.00003202255,0.0001375134,0.000008915865,0.000004502324,0.0006298863],"genre_scores_gemma":[0.9990312,0.0001175651,0.0004977891,0.0001794268,0.00003209863,0.000002781096,0.00008027005,0.0000056908,0.00005315006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009776718,"threshold_uncertainty_score":0.2513707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009786688706743894,"score_gpt":0.2635121786493482,"score_spread":0.2537254899426044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}