{"id":"W2102954277","doi":"10.1084/jem.20110846","title":"Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma","year":2011,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; American Society of Clinical Oncology; Leukemia Research Foundation; Lymphoma Research Foundation; Canadian Cancer Society Research Institute; Dana Foundation","keywords":"Kinase; Cancer research; PIM1; Protein kinase B; PI3K/AKT/mTOR pathway; Translation (biology); Biology; Signal transduction; EIF4E; Cell biology; Phosphorylation; Gene; Genetics; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008702692,0.0001394007,0.0003759612,0.0001062075,0.00005561674,0.000004226201,0.00008338374,0.00004311383,0.0007136532],"category_scores_gemma":[0.00002157748,0.00008409149,0.00003892711,0.00008983847,0.0001114181,0.00009011397,0.00001394487,0.0001356171,6.954955e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008056062,"about_ca_system_score_gemma":0.00003721384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000565609,"about_ca_topic_score_gemma":0.000009232251,"domain_scores_codex":[0.9987877,0.00009183299,0.0004751827,0.00009711363,0.000376758,0.0001714178],"domain_scores_gemma":[0.999413,0.00009774909,0.0002301033,0.00008849319,0.00004889936,0.0001218021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001658341,0.0002557803,0.0006889338,0.00001241862,0.00006694866,0.00008327684,0.01419954,0.000002642366,0.9788377,0.00004751042,0.0002784203,0.003868519],"study_design_scores_gemma":[0.01275093,0.004009284,0.0008002549,0.0006140436,0.0001358316,0.0006189519,0.02804836,0.000208629,0.9519807,0.0002582507,0.0004200386,0.0001547453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590265,0.03852744,0.0005413063,0.0007036662,0.000387318,0.0001959831,0.000001734098,0.000007367887,0.0006087006],"genre_scores_gemma":[0.9981001,0.000920722,0.0002039521,0.0004156665,0.0002828351,0.00000271511,0.000002178033,0.00001754094,0.00005431437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03907359,"threshold_uncertainty_score":0.7814001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03904586285399698,"score_gpt":0.2933396574992813,"score_spread":0.2542937946452843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}