{"id":"W2102978910","doi":"10.1210/en.2004-0495","title":"Pdx-1 Is Not Sufficient for Repression of Proglucagon Gene Transcription in Islet or Enteroendocrine Cells","year":2004,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Proglucagon; Enteroendocrine cell; Islet; Biology; Alpha cell; Gene expression; Prohormone convertase; Internal medicine; Transcription factor; Endocrinology; Cell biology; Gene; Molecular biology; Glucagon-like peptide-1; Beta cell; Hormone; Endocrine system; Prohormone; Insulin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001936233,0.0003020324,0.0004242055,0.0002166192,0.0001537838,0.0006636682,0.000300167,0.0002929103,0.001681721],"category_scores_gemma":[0.0003209224,0.0002164986,0.0002730606,0.0001283015,0.0002697871,0.0002619302,0.0003063336,0.0008459311,0.0005807854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004576353,"about_ca_system_score_gemma":0.0004342183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006431092,"about_ca_topic_score_gemma":0.0008601688,"domain_scores_codex":[0.9997392,0.00003507915,0.00003914979,0.00006041938,0.00007647565,0.00004965354],"domain_scores_gemma":[0.999479,0.0002098466,0.00008737985,0.00008209626,0.00003564499,0.00010614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004620012,0.00002419092,0.0002671657,0.00003076696,0.000003688732,0.00004798305,0.00001202933,0.00004960445,0.9988967,0.00005158268,0.00002440279,0.0005455587],"study_design_scores_gemma":[0.00002978646,0.0002499442,0.01137655,0.00001253217,0.00001601364,0.0003746182,0.00006316284,0.001139511,0.9833111,0.00003436184,0.003386409,0.000006076607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954575,0.001116035,0.001552087,0.00008532326,0.00003765919,0.00002514561,0.0004831742,0.00006486998,0.001178258],"genre_scores_gemma":[0.9911698,0.0007484214,0.001693146,0.00006842211,0.00001593523,0.00005467498,0.002341044,0.00003959224,0.003868926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001681721,"threshold_uncertainty_score":0.005625904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03539250150777105,"score_gpt":0.3001419155987737,"score_spread":0.2647494140910027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}