{"id":"W2102983882","doi":"10.1186/s13578-015-0003-4","title":"Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3β pathway in isolated aging rat hearts","year":2015,"lang":"en","type":"article","venue":"Cell & Bioscience","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"National Natural Science Foundation of China","keywords":"Cardioprotection; Oxidative stress; Protein kinase B; PI3K/AKT/mTOR pathway; Cystathionine gamma-lyase; Medicine; Reactive oxygen species; Pharmacology; LY294002; Internal medicine; Chemistry; Apoptosis; Endocrinology; Ischemia; Cell biology; Biology; Biochemistry; Cystathionine beta synthase; Cysteine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001935508,0.0005766389,0.0004411238,0.0002295223,0.0001408684,0.0001700108,0.0002144591,0.0002289367,0.000979822],"category_scores_gemma":[0.00009227274,0.0001673352,0.0003845061,0.0001076645,0.0003134251,0.0003046409,0.0002340731,0.0006631995,0.0001074948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401745,"about_ca_system_score_gemma":0.0003242126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004626206,"about_ca_topic_score_gemma":0.0007727904,"domain_scores_codex":[0.9999294,0.000009435948,0.00001035427,0.00001610411,0.00001167413,0.00002302728],"domain_scores_gemma":[0.9999288,0.000004378949,0.0000224922,0.000008037146,0.000008951151,0.0000272459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002449819,0.0002941569,0.0004562446,0.0002344061,0.00003372373,0.0001497019,0.00004602472,0.00009019182,0.9916524,0.0001160899,0.00009155361,0.004385735],"study_design_scores_gemma":[0.0003603642,0.004631362,0.01420888,0.00002870969,0.0001501522,0.000233303,0.00008390917,0.00103892,0.9775106,0.000161804,0.001577837,0.00001405388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934962,0.004097003,0.001412282,0.0001277807,0.00007756712,0.00003395106,0.0001316374,0.00007906313,0.0005445464],"genre_scores_gemma":[0.9947996,0.002430108,0.001264008,0.00009480256,0.00003659732,0.00006320568,0.0002461844,0.00001170327,0.001053712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000979822,"threshold_uncertainty_score":0.003277779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215196548741945,"score_gpt":0.2315440642025705,"score_spread":0.219392098715151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}