{"id":"W2102998087","doi":"10.1021/jo062385v","title":"Directed <i>Ortho</i> Metalation−Cross Coupling Strategies. <i>N</i>-Cumyl Arylsulfonamides. Facile Deprotection and Expedient Route to 7- and 4,7-Substituted Saccharins","year":2007,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Metalation; Chemistry; Amide; Table (database); Combinatorial chemistry; Aryl; Medicinal chemistry; Organic chemistry; Stereochemistry; Computer science; Database","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854359,0.0007575142,0.0002682119,0.0001747912,0.0001714446,0.0002244222,0.0004260209,0.0001996417,0.002161143],"category_scores_gemma":[0.0001536941,0.0002165794,0.0001943882,0.0001613051,0.0002418585,0.0002452944,0.0003672032,0.0004508765,0.001063887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003963443,"about_ca_system_score_gemma":0.0003827995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007085959,"about_ca_topic_score_gemma":0.00188434,"domain_scores_codex":[0.9998428,0.00002550378,0.0000147945,0.00003451965,0.00003694693,0.00004540348],"domain_scores_gemma":[0.9999132,0.000007262588,0.000032978,0.00001743198,0.00001188944,0.00001711802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001154792,0.00003823382,0.0001307688,0.00009121181,0.000009076662,0.0001188334,0.00004314589,0.0001399836,0.9941048,0.0008853314,0.0002448738,0.004078313],"study_design_scores_gemma":[0.00001846318,0.0002537466,0.0005070431,0.000003622278,0.00001093951,0.000286572,0.00001484491,0.00031871,0.9929455,0.00007389914,0.00555741,0.000009307894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9334142,0.002388489,0.03691705,0.0002378547,0.0001565115,0.0003561497,0.001041264,0.0006872879,0.02480124],"genre_scores_gemma":[0.9678119,0.001856001,0.01943225,0.000160744,0.00002815249,0.0001719191,0.00072571,0.00008205804,0.009731237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002161143,"threshold_uncertainty_score":0.007229745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101492350951063,"score_gpt":0.2457314757802575,"score_spread":0.2355822406851512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}