{"id":"W2103000254","doi":"10.1084/jem.20031705","title":"The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells","year":2004,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Western University","funders":"Canadian Institutes of Health Research; Biogen","keywords":"CD40; CD28; Signal transduction; Cell biology; Phosphorylation; ZAP70; Biology; Tyrosine phosphorylation; Transmembrane protein; T cell; Signal transducing adaptor protein; Molecular biology; Receptor; Immunology; Biochemistry; Cytotoxic T cell; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128138,0.0001750948,0.0001437249,0.0001245837,0.0001174225,0.0002535532,0.0000728151,0.0002059397,0.001070653],"category_scores_gemma":[0.0001750447,0.00006997633,0.0001232265,0.0001193598,0.0001304546,0.0001111024,0.0001037568,0.0002867704,0.0003410737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314753,"about_ca_system_score_gemma":0.0001372198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003814675,"about_ca_topic_score_gemma":0.0002579752,"domain_scores_codex":[0.9998544,0.00004235176,0.000009527924,0.00002304774,0.00003000364,0.00004052912],"domain_scores_gemma":[0.9999487,0.00001445908,0.000008744822,0.000007999667,0.000006448827,0.00001361414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001939835,0.00002641102,0.0002059404,0.00002042155,0.000002090781,0.0001150038,0.00002746165,0.00005434789,0.9976413,0.00009230351,0.0000403113,0.001580285],"study_design_scores_gemma":[0.00005481623,0.0007263041,0.005132008,0.000004623852,0.0000144479,0.001003949,0.0000606297,0.0008648974,0.9892098,0.000133032,0.002790694,0.000004707631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971289,0.001365455,0.0005686962,0.00005628026,0.00001142556,0.00001468136,0.0000952124,0.00001900529,0.0007404723],"genre_scores_gemma":[0.9980776,0.000805821,0.0004064504,0.00002828949,0.000009930316,0.00001925808,0.0001718049,0.000003781198,0.0004771007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070653,"threshold_uncertainty_score":0.003581703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01118885113097091,"score_gpt":0.2613121634760334,"score_spread":0.2501233123450625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}