{"id":"W2103008543","doi":"10.1534/genetics.104.029033","title":"Uncovering Novel Cell Cycle Players Through the Inactivation of Securin in Budding Yeast","year":2004,"lang":"en","type":"article","venue":"Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Securin; Separase; Biology; Anaphase; Budding yeast; Anaphase-promoting complex; Cell biology; Cell cycle; Genetics; Mitosis; Cell cycle checkpoint; CDC20; Gene; Activator (genetics); Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005678127,0.00008812459,0.0000758794,0.00001992398,0.00003162639,0.000008310803,0.000138136,0.00008734659,0.000002023171],"category_scores_gemma":[0.00001204834,0.00007849582,0.00003909219,0.00008965087,0.00003623589,0.000002940601,0.00008360129,0.00006927629,0.000001650137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002700743,"about_ca_system_score_gemma":0.00005683144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000984979,"about_ca_topic_score_gemma":0.0002227666,"domain_scores_codex":[0.9994555,0.000009817611,0.0001604056,0.0001539211,0.00007384632,0.0001465004],"domain_scores_gemma":[0.9996659,0.000004543841,0.00007196574,0.0002144181,0.00002709784,0.00001606248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001220576,0.00005430542,0.000502401,0.00001232093,0.00000768666,3.391356e-7,0.000338994,0.08251175,0.9161399,0.0002042295,0.00001855296,0.0001973079],"study_design_scores_gemma":[0.0006307297,0.00006953603,0.001329166,0.00001716133,0.000006766656,0.000003824572,0.0004004928,0.0001516067,0.9936862,0.0002455415,0.003356796,0.0001021846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822188,0.0002866576,0.01646195,0.000037595,0.00007145507,0.000114199,0.00001508099,0.000003104187,0.0007911432],"genre_scores_gemma":[0.9963042,0.0002497991,0.003191701,0.0001052656,0.00006660792,0.00000580358,0.00002508363,0.00001488459,0.00003671283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08236014,"threshold_uncertainty_score":0.3200966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007599548084060461,"score_gpt":0.2260913180150612,"score_spread":0.2184917699310007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}