{"id":"W2103013707","doi":"10.3389/fgene.2013.00131","title":"Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond","year":2013,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":446,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Cancer Foundation; U.S. Department of Energy","keywords":"Micronucleus test; Micronucleus; Epigenetics; Genetics; Genotoxicity; Genome instability; Biology; Chromosome instability; Cytokinesis; DNA damage; Clastogen; Cell division; Gene; Chromosome; Cell; Cell biology; DNA; Chemistry; Toxicity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002685583,0.001347168,0.001719803,0.002757022,0.0005091288,0.001332316,0.0009102936,0.001506794,0.001200809],"category_scores_gemma":[0.001430582,0.000375628,0.0004538772,0.002117644,0.001719267,0.001115755,0.00153393,0.001131987,0.0007996073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072441,"about_ca_system_score_gemma":0.001394993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001533902,"about_ca_topic_score_gemma":0.00258705,"domain_scores_codex":[0.9976696,0.0008215811,0.0001563223,0.000346203,0.0008896898,0.0001165311],"domain_scores_gemma":[0.9986093,0.0005061503,0.0002383206,0.00008029301,0.0004854162,0.0000804239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003153386,0.0001477618,0.01576468,0.007784049,0.0001512205,0.001372808,0.000676848,0.002480331,0.4607937,0.01350136,0.00290585,0.494106],"study_design_scores_gemma":[0.00003969677,0.002659916,0.08290311,0.003691398,0.0004761175,0.01723862,0.001623661,0.004826123,0.4367129,0.03647129,0.4130804,0.0002766735],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05682613,0.7842321,0.1363967,0.003170863,0.0006215958,0.0004094506,0.0006851621,0.0005382717,0.01711976],"genre_scores_gemma":[0.2419924,0.5862954,0.1521462,0.0021397,0.0006248663,0.0006104317,0.0008467383,0.000140936,0.01520327],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002757022,"threshold_uncertainty_score":0.01420283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005295992445973187,"score_gpt":0.2368724494399501,"score_spread":0.2315764569939769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}