{"id":"W2103015871","doi":"10.1038/ncomms2599","title":"Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Queen's University Belfast; Queen's University; Cancer Research UK; Peter MacCallum Cancer Centre; Wellcome Trust; University of Dundee","keywords":"Transcription factor II D; RNA polymerase I; RNA polymerase II; Topoisomerase; Molecular biology; Biology; Transcription (linguistics); Polymerase; Transcription factor II B; General transcription factor; Abortive initiation; RNA polymerase II holoenzyme; Cell biology; RNA-dependent RNA polymerase; DNA; Promoter; Gene; Biochemistry; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056883,0.0001032107,0.00009456529,0.00004913298,0.0001554931,0.00002603813,0.0002751604,0.0001904164,0.0000350447],"category_scores_gemma":[0.00004940952,0.0001063332,0.00005985027,0.0001141145,0.00004624677,0.000037703,0.00004969164,0.0001856401,0.000003069714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002572283,"about_ca_system_score_gemma":0.00002874711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009523438,"about_ca_topic_score_gemma":0.00007230622,"domain_scores_codex":[0.9992922,0.00009299141,0.0002533928,0.0001321925,0.0001165477,0.0001126627],"domain_scores_gemma":[0.9989338,0.00003236192,0.0001676672,0.0005988288,0.0002294806,0.00003788255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001603166,0.00008893378,0.00002604607,0.00001738301,0.00002080596,5.782665e-9,0.0003698343,0.000006737675,0.9837384,0.0008000318,0.001064657,0.01385114],"study_design_scores_gemma":[0.0004167604,0.0001397577,0.0008661654,0.00001984943,0.00001829072,0.000001321016,0.0003292791,0.002390183,0.9837754,0.0004060612,0.01150538,0.000131489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680887,0.002452257,0.02485326,0.002596766,0.00007803863,0.0007972842,0.000169444,0.00003051453,0.0009337115],"genre_scores_gemma":[0.9925379,0.000351005,0.003897388,0.0004393605,0.00002859092,0.0001263811,0.002530737,0.000012555,0.00007613497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02444912,"threshold_uncertainty_score":0.4336142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02349026908128578,"score_gpt":0.2935286187963891,"score_spread":0.2700383497151034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}