{"id":"W2103015871","doi":"10.1038/ncomms2599","title":"Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation","year":2013,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Queen's University Belfast; Queen's University; Cancer Research UK; Peter MacCallum Cancer Centre; Wellcome Trust; University of Dundee","keywords":"Transcription factor II D; RNA polymerase I; RNA polymerase II; Topoisomerase; Molecular biology; Biology; Transcription (linguistics); Polymerase; Transcription factor II B; General transcription factor; Abortive initiation; RNA polymerase II holoenzyme; Cell biology; RNA-dependent RNA polymerase; DNA; Promoter; Gene; Biochemistry; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106895,0.0006231893,0.000339494,0.0002949211,0.0001689164,0.0006742921,0.000243977,0.0002973866,0.00266364],"category_scores_gemma":[0.0002448248,0.000245749,0.000351041,0.0001674944,0.0002482978,0.0003032901,0.000292201,0.0007956158,0.001099505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005507612,"about_ca_system_score_gemma":0.0003825642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006660983,"about_ca_topic_score_gemma":0.0008439703,"domain_scores_codex":[0.9997168,0.00004208801,0.00001611397,0.00006182084,0.0001059431,0.00005718126],"domain_scores_gemma":[0.9997684,0.00002509059,0.00006194638,0.00002736926,0.0000469601,0.00007020662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008914439,0.00001585033,0.0001839703,0.00006902243,0.00000592491,0.00003435846,0.000008238695,0.0000537064,0.9975392,0.0001303559,0.0001184956,0.001751707],"study_design_scores_gemma":[0.00001387022,0.0001608304,0.003589988,0.00001036209,0.000008139563,0.0001141425,0.00001575662,0.000362097,0.9894407,0.00009898699,0.006181053,0.000003934752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8895952,0.05047269,0.0382801,0.001267471,0.0008829959,0.0002029622,0.001900716,0.001487176,0.01591079],"genre_scores_gemma":[0.9843434,0.005403621,0.003971122,0.0001066143,0.0000815458,0.00004960197,0.0008463432,0.00004170301,0.005155876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00266364,"threshold_uncertainty_score":0.008910775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02349026908128578,"score_gpt":0.2935286187963891,"score_spread":0.2700383497151034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}