{"id":"W2103040842","doi":"10.1534/genetics.112.140962","title":"Temporal Variation in Selection Accelerates Mutational Decay by Muller’s Ratchet","year":2012,"lang":"en","type":"article","venue":"Genetics","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Variation (astronomy); Genetics; Selection (genetic algorithm); Ratchet; Mutation; Evolutionary biology; Gene; Physics; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008520989,0.0002702634,0.0003570191,0.0005700255,0.0002126165,0.0004956945,0.0003169877,0.000308185,0.001213201],"category_scores_gemma":[0.003324333,0.0002369107,0.0005123377,0.0002812532,0.0007768095,0.0005711374,0.000551442,0.0004812766,0.0002323332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004334266,"about_ca_system_score_gemma":0.0003159344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005652611,"about_ca_topic_score_gemma":0.0007251038,"domain_scores_codex":[0.9996742,0.00009800086,0.00002380724,0.00007993358,0.00007366797,0.00005035274],"domain_scores_gemma":[0.9981142,0.0007190178,0.0006205525,0.0002999013,0.0001411182,0.0001052061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006647332,0.0002113536,0.07682025,0.0002896127,0.0002184424,0.001026218,0.0006877551,0.03113676,0.7812721,0.04118734,0.0007781685,0.0657072],"study_design_scores_gemma":[0.0002252299,0.002609774,0.3442277,0.0001020726,0.000335225,0.005973803,0.0003654025,0.367892,0.2127583,0.05598619,0.009206588,0.0003176638],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985796,0.0005109636,0.01166941,0.0001417007,0.0000200115,0.00001232088,0.00002018589,0.0001656183,0.001663921],"genre_scores_gemma":[0.997884,0.0001552946,0.001537862,0.0000363411,0.000007891046,0.000009219129,0.00001051493,0.00001262259,0.0003462866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213201,"threshold_uncertainty_score":0.00450635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008632488407555483,"score_gpt":0.2561379267031338,"score_spread":0.2475054382955784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}