{"id":"W2103072285","doi":"10.1016/j.bbagen.2015.04.014","title":"IDH1, lipid metabolism and cancer: Shedding new light on old ideas","year":2015,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"University of Toronto","keywords":"IDH1; Isocitrate dehydrogenase; Lipid metabolism; Biology; Peroxisome; Cancer research; Cancer; Biochemistry; Mutant; Enzyme; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0003667138,0.001549499,0.002660731,0.0003222224,0.0002164617,0.0002532919,0.0009373247,0.001065084,0.00002906747],"category_scores_gemma":[0.00009824407,0.001311236,0.00103723,0.0005489809,0.0001766089,0.00002835691,0.0006104652,0.0006991647,0.00005431788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000132819,"about_ca_system_score_gemma":0.001716269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005114888,"about_ca_topic_score_gemma":0.00009427798,"domain_scores_codex":[0.99495,0.000401313,0.0009248096,0.002021414,0.0006133587,0.001089107],"domain_scores_gemma":[0.9967383,0.00003980811,0.0007578791,0.001399382,0.0001712508,0.0008933584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002316851,0.0002112111,3.134008e-7,0.001962519,0.001183644,0.000001689282,0.0001913257,0.000003827167,0.3769074,0.0007285993,0.3007334,0.3178444],"study_design_scores_gemma":[0.0009238106,0.0002283226,0.00001326961,0.001188686,0.001276833,0.00002996425,0.000008675423,0.000003101248,0.06647874,0.00006842056,0.9283422,0.001438001],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02614366,0.9592133,0.00000491464,0.0004584813,0.01157459,0.001135449,0.0005020554,0.00009577297,0.0008717651],"genre_scores_gemma":[0.0005422393,0.9273126,0.0002828362,0.001041788,0.06465267,0.0002334744,0.0009137389,0.0002917743,0.004728912],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6276088,"threshold_uncertainty_score":0.9997253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241866560546217,"score_gpt":0.307010404680109,"score_spread":0.2828237486254873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}